Schering Aktiengesellschaft

Solvay & Cie

Berlex Laboratories, Inc.

Schering Altiengesellschaft

William H Andrews

David Richard Light

Robert Michael Wydro

Patricia Ann Young

Jeffrey Homer Clarke

Karel Z Newman, Jr

James G Files

Michael T McCaman

John L Tedesco

Thomas C Gore

Virginia M Brothers

Stacey R Sias

Irene Kuhn

Michael John Morser

Leland S Paul

Leland Shawn Paul

Laura R Vilander

The present invention relates to the single-chain thrombomodulin ('TM') and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.

Protease-resistant thrombomodulin analogs

Mutagenesis methods and compositions

Nucleic acid molecules are provided which encode antigenic proteins capable of inducing in a chicken an immune response conferring protection against Eimeria tenella. Expression vectors containing the nucleic acid molecules are also provided. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.

DNA encoding an antigenic protein derived from Eimeria tenella and

A genomic DNA molecule having the nucleic acid sequence set forth in FIG. 1 and encoding an antigenic protein derived from Eimeria tenella has been isolated. The protein has a molecular weight of about 25,000 daltons and is composed of two polypeptides joined by a disulfide bond. One of the polypeptides is characterized by a molecular weight of about 17,000 daltons and by a blocked N-terminal amino acid and having the amino acid sequence set forth in FIG. 1. The other polypeptide is characterized by a molecular weight of about 8,000 daltons and has the amino acid sequence set forth in FIG. 1. A cDNA molecule encoding the 25,000 dalton polypeptide with a continuous amino acid sequence has been inserted into expression vectors capable of expressing the 25,000 dalton polypeptide directly or as a fused polypeptide. The polypeptides produced are used in vaccines to immunize chickens against infection by Eimeria tenella.

Growing community of inventors

San Mateo, CA, United States of America

William H Andrews