Massachusetts Institute of Technology

Tokitae LLC

Elwha LLC

William Gates

Lowell L Wood, Jr

Roderick A Hyde

Clarence T Tegreene

Jordin T Kare

Nathan P Myhrvold

Muriel Y Ishikawa

Robert Samuel Langer

Victoria Y H Wood

Charles Whitmer

Tony S Pan

David Bazeley Tuckerman

Alistair K Chan

Robert C Petroski

Jesse R Cheatham, Iii

Philip Andrew Eckhoff

Geoffrey Frank Deane

Nels R Peterson

Shieng Liu

David J Yager

Fong-Li Chou

Lawrence Morgan Fowler

Stephany Yi Tzeng

Fridrik Larusson

Robert S Langer, Jr

Thanh Duc Nguyen

Jennifer Ezu Hu

James J Norman

Ana Jaklenec

Philip A Welkhoff

Brian L Pal

David Keith Piech

Boris Nikolic

Maurizio Vecchione

Kevin McHugh

Xian Xu

Edward KY Jung

Jesse R Iii Cheatham

Emulsion-based and micromolded ('MM') or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

Micromolded or 3-D printed pulsatile release vaccine formulations

Growing community of inventors

Redmond, WA, United States of America

William Gates