Encore Health LLC

Novartis Ag

Urigen, Inc.

William Garner

Margaret Garner

George Edward Minno

David M Gooden

Ronald D Blum

Amie Franklin

William R Burns

Michael Flashner

Michael Sember

C Parsons

Provided herein are pharmaceutical compositions comprising a therapeutically effective amount of lipoic acid choline ester or derivatives thereof and a non-aqueous excipient mixed in an aqueous solution. Also provided herein are non-aqueous compositions prepared by mixing the therapeutically effective amount of lipoic acid choline ester and the non-aqueous excipient. The non-aqueous compositions can be further mixed with the aqueous solution.

Lipoic acid choline ester compositions and methods of use

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

Method of treating presbyopia using dithiol compounds and their derivatives

Dithiol compounds, derivatives, and uses therefor

Compositions containing low doses of lipoic acid-based active agents and methods for using the same are provided. In particular, compositions containing low dose lipoic acid, lipoic acid derivatives, said lipoic acid seleno-derivatives and are provided to prevent and/or treat ocular diseases.

Low dose lipoic acid pharmaceutical compositions and methods

Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

Choline esters

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating an ocular disease, especially presbyopia and cataract. Also provided are methods of treating an ocular disease, the methods comprising administering to a subject an active agent and an adjunctive agent.

Methods of treating ocular diseases using derivatives of lipoic acid

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract. Also disclosed are novel mercaptan compounds, particularly those including a photolabile protecting group, as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

Dithiol compounds and treatment of presbyopia using said compounds

Compositions containing low doses of lipoic acid-based active agents and methods for using the same are provided. In particular, compositions containing low dose lipoic acid, lipoic acid derivatives, and lipoic acid seleno-derivatives and are provided to prevent and/or treat ocular diseases.

Low dose lipoic and pharmaceutical compositions and methods

Methods of treating ocular diseases using dithiol compounds, their derivatives, and pharmaceutically acceptable salts thereof are disclosed. In particular, methods using dithiol compounds that comprise derivatives of lipoic acid are described. The dithiol compounds are especially useful for treating ocular diseases such as presbyopia and cataract.

Novel mercaptan compounds, particularly those including a photolabile protecting group, are described as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

Growing community of inventors

Eastport, ME, United States of America

William Garner