Fziomed, Inc.

William G Oppelt

Stephanie M Cortese

Herbert E Schwartz

John M Blackmore

Mark E Miller

Richard Berg

Samuel J Falcone

Ronald F Haynes

Greg Graham

The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then used as fluids, gels or foams. By providing a product bag, the compositions can be delivered as gels or as sprays. By dissolving propellant gases in the compositions, the materials can be delivered as foams, which have decreased density, and therefore can adhere to surfaces that previously have been difficult to coat with antiadhesion gels. Delivery systems can also provide mechanisms for expelling more product, and for directing the flow of materials leaving the delivery system. Bioresorbable, bioadhesive, anti-adhesion, and/or hemostatic compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The biological and physical properties of such compositions can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by selecting the solids content of the composition. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

Polyacid/polyalkylene oxide gels and methods for their delivery

The present invention relates to improved methods for filling the skin for cosmetic or medical purposes. Compositions comprising carboxymethyl cellulose (CMC), polyethylene oxide (PEO) and calcium ions can be made and have physical properties that depend on the amounts and types of CMC, PEO, and calcium ions to form ioniclaly cross-linked gels. Compositions can be formed into microspheres, coascervates, gels, or membranes. Gels, microspheres and coascervates can be injected directly into a site for dermal filling. Membranes can be surgically introduced, where they swell to form hydrated gels. After introduction, the dermal filler persists for a period of time and then can disintegrate and be removed from the body.

Compositions of polyacids and polyethers and methods for their use as dermal fillers

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as fluids or microspheres. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

Compositions of polyacids and polyethers and methods for their use in reducing adhesions

Polyacid/polyalkylene oxide foams and gels and methods for their delivery

A device for inserting a substantially square sheet of flexible material through a laparoscopic cannula into an abdominal cavity. The device is an elongate, generally cylindrical member having a proximal end and a distal end and a body portion therebetween. A pair of tines is rigidly affixed to the distal end of the body portion with a slot separating the tines. A handle is affixed to the proximal end of the body portion. The slot defined between the pair of tines is dimensioned to accommodate the sheet thickness therewithin. In a preferred use, the sheet of material is inserted between the tines with diagonal corners of the sheet within the slot. The free corners of the sheet are drawn together with one hand and the handle of the device is rotated to wrap the sheet around the exterior surface of the two tines. The distal end of the body portion is then inserted into a laparoscopic cannula and advanced therethrough with a twisting motion until the distal end of the device emerges from the cannula positioned within the abdominal cavity. At this point, the device is slightly withdrawn to dislodge the film from the receptacle at the base of the tines and the sheet unwinds from around the tines, effectively unfolding the sheet within the target cavity. The sheet is finally released from the slot between the tines when the device is withdrawn from the cannula; the sheet remaining within the abdominal cavity.

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Arroyo Grande, CA, United States of America

William G Oppelt