Bioform, Inc.

Merz Aesthetics, Inc.

Cap Biomaterials, LLC

William G Hubbard

Lawrence A Shimp

Timothy R Devine

Keith A Orlowski

Calcium phosphate and related coating powder particles comprising a surface component comprising a silicate content, plasma sprayed coatings thereof on implantable medical/dental devices, and bone grafting materials of such coated particles. Optionally, biologically active agents such as bone morphogenetic proteins, growth factors, analgesics, and antibiotics can be incorporated therein.

Glassy calcium phosphate particulates, coatings and related bone graft materials

A material and method for augmenting soft tissue. The tissue augmentation material consists essentially of water and a polysaccharide gel former selected from the group consisting of a cellulose polysaccharide, starch, chitin, chitosan, hyaluronic acid, hydrophobe modified polysaccharide, an alginate, a carrageenan, agar, agarose, an intramolecular complex of a polysaccharide, an oligosaccharide and a macrocylic polysaccharide. Glycerin may also be included. The material may be used to augment soft tissue in a variety of areas, including the facial region and vocal folds.

Tissue augmentation material and method

A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

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Burlington, WI, United States of America

William G Hubbard