Bausch-lomb Incorporated

Deichert, William G.

Wrue, Richard J.

Cook, William H.

Westfall, Norman R.

William G Deichert

Kai C Su

Gary D Friends

Joon S Park

John B Melpolder

Martin F Van Buren

Rajan S Bawa

Richard J Wrue

Martin F VanBuren

Joseph J Falcetta

Richard C Chromecek

Gregory C Niu

William H Cook

Martin F vanBuren

Norman R Westfall

A method for forming a contact lens comprising subjecting a soft contact lens impregnated with a polymerizable liquid composition which may be polymerized in said lens to render said lens relatively rigid and which may be polymerized upon exposure to radiation with radiation in a selected manner so as to render selected portions of said lens relatively rigid.

Method of making variable modulus lenses

The physical properties of highly oxygen-permeable continuous-wear contact lenses, comprising a copolymer of an organosilicone monomer, a fluoroalkyl ester monomer and a hydrophilic monomer, are improved by the further addition of a linear polysiloxane oligomeric cross-linking agent with or without neopentylglycol dimethacrylate.

Continuous-wear lenses having improved physical properties

While polymerizing a contact lens monomer in a mold, grooves or other surface configurations are formed on the resulting polymeric lens surface by irradiating the monomer through a mask pattern which corresponds to the grooves or other desired configurations.

Manufacture of polymeric contact lenses

A sustained-release polymeric hydrogel dosage form useful for topical, systemic or transdermal administration of a medicinal agent comprising a cross-linked, polymerized hydrophilic polymer, an amino acid polymer, a cross-linking agent, and an optional hydrophobic monomer and/or a chain regulator in conjunction with a lower alkyl (C.sub.1 -C.sub.4), polar solvent and said medicinal agent in a therapeutically effective amount.

Sustained-release formulation containing an amino acid polymer with a

Hybrid contact lenses and other composite polymeric articles of precise dimensions are made by placing a first monomer composition in a mold and irradiating and polymerizing a central portion only with ultraviolet radiation. Unpolymerized monomer is removed, a second monomer composition is placed in contact with the polymer formed from the first monomer composition and the latter is polymerized by ultraviolet irradiation or by other means to obtain a composite article which is then machined to form a hybrid lens.

Method of making articles of dissimilar polymer compositions

Monomeric polysiloxanes endcapped with activated unsaturated groups are copolymerized with polycyclic modulus modifiers and tear film stabilizers to form hard, gas permeable, polysiloxane contact lenses and other biomedical devices.

Polysiloxane with polycyclic modifier composition and biomedical devices

Monomeric polysiloxanes endcapped with activated unsaturated groups are copolymerized with a modulus modifier and tear film stabilizers to form hard, gas permeable, polysiloxane contact lenses and other biomedical devices.

Polysiloxane composition and biomedical devices

Monomeric polysiloxanes endcapped with activated unsaturated groups are copolymerized with cycloalkyl modulus modifiers and tear film stabilizers to form hard, gas permeable, polysiloxane contact lenses and other biomedical devices.

Polysiloxane with cycloalkyl modifier composition and biomedical devices

Monomeric polysiloxanes end-capped with activated unsaturated groups are copolymerized with acrylic acid to form hydrophilic, water absorbing polysiloxane contact lenses. These contact lenses are unexpectedly capable upon hydration of retaining from 1 percent to about 99 percent by weight, based upon the total weight of the copolymer, of water.

Water absorbing contact lenses made from polysiloxane/acrylic acid

Monomeric polysiloxanes end-capped with activated unsaturated groups polymerized with acrylic acid and a comonomer comprising a polycyclic ester of acrylic acid or methacrylic acid to form a hydrophilic, water absorbing contact lens is disclosed. These polysiloxane polymer contact lenses are unexpectedly capable upon hydration of retaining from 1 percent to about 99 percent by weight of water, based upon the total weight of the dry, i.e., unhydrated polymer.

Polysiloxane/acrylic acid/polcyclic esters of methacrylic acid polymer

Monomeric polyparaffinsiloxanes end-capped with activated unsaturated groups and polymers and copolymers thereof are disclosed herein for use as contact lenses and biomedical devices with improved properties, such as, oxygen transportability, hydrolytic stability, biological inertness, transparency and improved strength without the use of fillers. The polymer composition comprises a poly(organoparaffinsiloxane) monomer .alpha.,.omega. terminally bonded through divalent hydrocarbon groups to polymerized free radical polymerizably activated unsaturated groups.

Polyparaffinsiloxane shaped article for use in biomedical applications

A shaped body is manufactured from at least two polymerized materials with one polymerized material being swellable relative to the other polymerized material. The shaped body is formed having sections of the first material, the second material and a substantially random copolymer of the first and second materials as a transition section between the first and second sections.

Shaped body of at least two polymerized materials and method to make same

A process is disclosed which involves the preparation of monomeric organosilicon esters in a much shorter time and at a much higher purification than previously known in the art. More specifically, the process comprises reacting a cyclosilalkoxane having the general formula: ##STR1## wherein R is a monovalent hydrocarbon radical free of aliphatic unsaturation, R' is selected from the group consisting of H and CH.sub.3 and n is an integral of from 1 to 2 inclusive with a free radical polymerizable monocarboxylic acid. The cyclosilalkoxane is contacted with the free radical polymerizable monocarboxylic acid in the presence of a solvent. The solvent forms an azeotropic mixture with the water formed by the reaction. During the reaction, the azeotropic mixture is continuously removed from the reaction. Also present in the reaction solution is a protonating acid catalyst and a free radical polymerization preventing inhibitor. The process further comprises heating the solution to a temperature which forces the reaction to completion at an accelerated rate. During the reaction sufficient oxygen is supplied to the reaction mixture in order to convert the inhibitor present in the reaction mixture from an inactive to an active form. This process forms a substantially pure free radical polymerizable monomeric unsaturated organosilicone ester in about 3 to about 6 hours.

Preparation of monomeric organosilicon esters

Monomeric polysiloxanes end-capped with activated unsaturated groups and polymers and copolymers thereof are disclosed herein for use as contact lenses and biomedical devices with improved properties, such as, oxygen transportability, hydrolytic stability, biological inertness, transparency and improved strength without the use of fillers. The polymer composition comprises a poly(organosiloxane) monomer .alpha.,.omega. terminally bonded through divalent hydrocarbon groups to polymerized free radical polymerizably activated unsaturated groups. Contact lenses and biomedical devices i.e. shaped article for use in biomedical applications made therefrom can be 'hard' or 'soft'. This hardness or softness is a function of the comonomer or the molecular weight of the monomers. Preferably the contact lenses and biomedical devices are 'soft'. The copolymer compositions of the instant invention comprise the polymerization product of the polysiloxane monomers and monomer or monomers containing an activated vinyl group. These polymers are employed to make biomedical devices and optical products, e.g. contact lenses, intraocular implants, etc.

Polysiloxane shaped article for use in biomedical applications

Monomeric polysiloxanes end-capped with activated unsaturated groups and polymers and copolymers thereof are disclosed herein for use as contact lenses with improved properties, such as, oxygen transportability, hydrolytic stability, biological inertness, transparency and improved strength without the use of fillers. The polymer composition comprises a poly(organosiloxane) .alpha., .omega. terminally bonded through a divalent hydrocarbon group to a polymerized activated unsaturated group. Contact lenses made therefrom can be, as commonly referred to, 'hard' or 'soft'. This hardness or softness is a function of the comonomer or the molecular weight of the monomers. Preferable the contact lenses are 'soft'. The copolymer compositions of the instant invention comprise the polymerization product of the polysiloxane monomers and monomer or monomers containing an activated vinyl group. These polymers are employed to make optical products, e.g. contact lenses, intraocular implants, etc.

Growing community of inventors

Macedon, NY, United States of America

William G Deichert