Wisconsin Alumni Research Foundation

William Franklin Dove

Michael Richard Sussman

Gregory Dean Kennedy

Perry Joseph Pickhardt

Alexandra Shedlovsky

Melanie Mae Ivancic

Mark Reichelderfer

Michael N Gould

Jill D Haag

Lawrence N Kwong

Adrian Daniel Hegeman

Xiaodi Chen

Edward Lee Huttlin

Jennifer Kathleen Pleiman

Amy Ann Irving

James M Amos-Landgraf

Edward Leo Huttlin

Gregory D Kennedy

Perry J Pickhardt

This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Methods for detection, staging, and surveillance of colorectal adenomas and carcinomas

This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Methods for detection and treatment of colorectal cancer

A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny of that rat. In addition, methods of using these rats are provided, including methods for screening a carcinogen or a promoter of carcinogenesis, and methods for screening preventive and inhibitory agents of carcinogenesis.

Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region

Methods for breeding mutagenized mice permit detection of genetic loci that in heterozygous mutated form can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the index phenotype. In the test generation, clusters of individuals are observed to deviate from the typical phenotype. The genetic material and molecules encoded thereby can be obtained using available methods. Improved and compact methods are also disclosed.

Method for identifying mutants and molecules

A method for breeding mutagenized mice that permits detection of genetic loci that can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the index phenotype. In the test generation, clusters of individuals are observed to deviate from the typical phenotype. The genetic material and molecules encoded thereby can be obtained using available methods.

Growing community of inventors

Madison, WI, United States of America

William Franklin Dove