Hemosonics LLC

University of Virginia Patent Foundation

Duke University

Other

Brown University

Homosonics LLC

Novason Corporation

William F Walker

Francesco Viola

Andrew Homyk

Gregory Vincent Browne

Bjarne Hansen

F Scott Corey

John Alexander Hossack

Travis N Blalock

Christopher Grant Denny

Robert Stanford Magyar

Elisa Ferrante

Tim Higgins

Frank Regan

Gregg E Trahey

David Bryant

Thomas Givens

Timothy Higgins

Daniel J Sorin

F William Mauldin, Jr

George D Konidaris

Adam Looker

William Floyd-Jones

Sean Murray

Bryan Roy

Michael B Lawrence

Kevin Owen

Drake A Guenther

Franklin F Regan

Cynthia Ann Lloyd

Franklin Francis Regan, Iv

Margaret Kramer Sande

Richard S Stack

Cynthia A Toth

Michael A Ellis

Kathryn R Nightingale

Elizabeth M Walker

Karthik Ranganathan

James H McElhaney

Richard E Davidsen

Paul D Freiburger

Michael I Fuller

William F Mauldin, Jr

Margaret D Kramer

Michael Jason McAllister

Howard G Clark

Phyllis Kornguth

Gary C-h Ng

Matthew Morgan

Franklin F Iv Regan

Jr F William Mauldin

A system for displaying a plurality of hemostatic indexes is disclosed. The system includes a communication receiver configured to receive the hemostatic indexes and a graphical user interface (GUI) connected to the communication receiver and configured to simultaneously display the hemostatic indexes. The hemostatic indexes are derived from a plurality of independent measurements, such as the mechanical measurements determined using the sonorheometry systems and processes.

Hemostatic parameter display

A motion planner of a computer system of a primary agent, e.g., an autonomous vehicle, uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the primary agent prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the primary agent, the system sets a probability of collision with another agent, e.g., a dynamic object, in the environment based at least in part on the collision assessment. Depending on whether the goal of the primary agent is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively low or relatively high potential of a collision with the particular dynamic object. The system then causes the actuator system of the primary agent to implement a motion plan with the applicable identified path based at least in part on the optimization.

Apparatus, method and article to facilitate motion planning in an environment having dynamic objects

A device for estimating a mechanical property of a sample is disclosed herein. The device may include a chamber configured to hold the sample; a transmitter configured to transmit a plurality of waveforms, including at least one forcing waveform; and a transducer assembly operatively connected to the transmitter and configured to transform the transmit waveforms into ultrasound waveforms. The transducer assembly can also transmit and receive ultrasound waveforms into and out of the chamber, as well as transform at least two received ultrasound waveforms into received electrical waveforms. The device also includes a data processor that can receive the received electrical waveforms; estimate a difference in the received electrical waveforms that results at least partially from movement of the sample; and estimate a mechanical property of the sample by comparing at least one feature of the estimated difference to at least one predicted feature, wherein the at least one predicted feature is based on a model of an effect of the chamber wall. Finally, the device can also include a controller configured to control the timing of the ultrasound transmitter and data processor.

Determining mechanical properties via ultrasound-induced resonance

A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.

Disposable system for analysis of hemostatic function

An ultrasound system for imaging a target is provided. The system includes a plurality of transducer elements; at least one transmitter configured to excite at least one of the transducer elements to emit ultrasound energy to the target; a plurality of samplers configured to sample echo signals received by at least some of the plurality of transducer elements, the echo signals comprising acoustic echoes received from the target responsive to the ultrasound energy; a coherence calculator configured to calculate a plurality of coherence values, each of the coherence values corresponding to a measure of similarity between at least two sample echo signals; an estimator configured to estimate a coherence contribution estimate, the coherence contribution estimate comprising an estimate of a contribution of at least one coherence model to the plurality of coherence values.

Methods, systems and computer program products for ultrasound imaging using coherence contribution

A motion planner of an autonomous vehicle's computer system uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the vehicle prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the vehicle, the system sets a probability of collision with a dynamic object in the environment based at least in part on the collision assessment. Depending on whether the goal of the vehicle is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively high or relatively low potential of a collision with the particular dynamic object. The system then causes the actuator system of the vehicle to implement a motion plan with the applicable identified path based at least in part on the optimization.

Apparatus, method and article to facilitate motion planning of an autonomous vehicle in an environment having dynamic objects

An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.

Characterization of blood hemostasis and oxygen transport parameters

Provided are devices, systems and methods for the use of a portable unit for the evaluation of hemostasis. For example, a portable system for determining a plurality of hemostatic parameters may be included. The system includes a blood sample receptacle, an analyzer and a housing. The blood sample receptacle is configured to hold at least one blood sample. The analyzer is configured to determine at least two hemostatic parameters of the at least one blood sample. The housing is configured to operably couple the blood sample receptacle and the analyzer. The housing is portable and may, for example, have a thickness of 17.5 cm or smaller.

Hemostasis analyzer

Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material.

Ultrasound-based method and related system to evaluate hemostatic function of whole blood

Growing community of inventors

Charlottesville, VA, United States of America

William F Walker