Cook Medical Technologies LLC

Cook Incorporated

Med Institute Incorporated

William F Moore

Darin Gene Schaeffer

David Eric Orr

Patrick H Ruane

Gary Bradford Shirley

Priscilla Reyes

Melinda S Morrell

Jeffry Scott Melsheimer

Siddharth Vad

Michael W Hardert

David Christian Lentz

Mark Robert Frye

Michael D Deckard

James Elsesser

Randy Joe Myers

Nathan Ridgley

Thomas A Kay

Priscilla T Reyes

Nathan S Ridgley

Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device. In a fourth embodiment, methods of treatment are provided that include implanting a coated medical device.

Medical device coatings for releasing a therapeutic agent at multiple rates

A hemostatic valve device for use in inserting an interventional device into a body lumen of a patient. The valve device includes a housing that defines a cavity between first and second end openings. A valve structure is disposed within the cavity, and defines a variable diameter channel for receiving the interventional device. An annular chamber is generally formed between the valve structure and the housing inner surface, and can be filled with fluid. The housing is movable between first and second positions so that the volume of the cavity and the diameter of the channel vary to a degree for the valve structure to form a seal along the interventional device inserted within the channel. The valve structure may be configured to seal without substantial twisting.

Adjustable diameter hemostatic valve

A method of coating a stent is provided that minimizes damage to the coating. The stent is self-expanding and made of a superelastic material. The stent is initially cooled so that at least part of the structure of the stent transforms to a martensitic phase. The stent is then compressed, coated and loaded while the structure of the stent remains at least partially martensitic. After the stent is loaded into a tubular restraint, the loaded stent is allowed to warm to room temperature.

Method of coating a stent

The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate. A medical device that incorporates the multiple balloon assembly of the present disclosure, as well as a method for using the medical device and multiple balloon assembly are further disclosed.

Therapeutic agent delivery device with a dual balloon having distal taper apertures

A spring action medical device includes a spring that may propel a hammer component in a distal direction when the spring is released from a loaded state. When propelled forward by the spring, the hammer component makes contact with a distal tip of the medical device. The distal tip may then transfer a force to an external object, such as an occlusion in a body lumen.

Spring action medical device

An electrospinning apparatus may include a first spinneret and a second spinneret, each including a reservoir and an orifice. The first and second spinnerets may have first and second electrical charges, respectively. The first spinneret orifice may be located substantially opposite the second spinneret orifice. The first and second spinnerets may be used to prepare a medical device defining a lumen with a proximal end, a distal end, a luminal surface and an abluminal surface. The first spinneret orifice distal end may be configured to be located outside of the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device abluminal surface. The second spinneret orifice distal end may be configured to be located in the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device luminal surface.

Needle-to-needle electrospinning

A dual balloon catheter assembly and method of use thereof are provided. The dual balloon catheter assembly may be used in a cryoplasty treatment that is provided in combination with eluting an antiproliferative to reduce and/or eliminate vessel fractures, thereby inhibiting proliferative response after angioplasty.

Dual balloon catheter assembly

A delivery system for a medical device may include a sheath, a catheter slideably disposed within the sheath, and a hemostatic device comprising a housing disposed around and sealingly engaged with the sheath by a first seal. A sleeve is slideably coupled to the catheter and comprises a second seal sealingly engaging the catheter. The sleeve is movable between a first position, in which the sleeve is disposed outside of the housing and the first seal is sealingly engaged with an outer surface of the catheter, and a second position in which at least a portion of the sleeve is disposed within the housing between an inner surface of the housing and the outer surface of the catheter, wherein, in the second position, the first seal is sealingly engaged with an outer surface of the sleeve and the second seal is sealingly engaged with the outer surface of the catheter.

Graft deployment assist tool

This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.

Taxane coatings for implantable medical devices

The disclosure relates to a method and apparatus for coating a medical device. The method includes providing an electrospinning apparatus and simultaneously electrospinning at least one solution onto a first surface and an opposing second surface. The apparatus comprises a first spinneret and a second spinneret. An energy source is electrically coupled to the first spinneret and the second spinneret. The first spinneret and second spinneret comprise a reservoir and an orifice fluidly coupled to the reservoir. The first spinneret orifice is located substantially opposite the second spinneret orifice.

Methods are provided for coating a first surface of a device while also preventing coating of a second surface of the device by forming a covering of solid carbon dioxide on the second surface. In one embodiment of the invention, a method is provided for coating a luminal surface of a device while masking the abluminal surface with a covering of solid carbon dioxide. In another embodiment, a method is provided for coating the abluminal surface of the device while covering the luminal surface of the device with solid carbon dioxide.

Process for coating a portion of an implantable medical device

This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

Growing community of inventors

Bloomington, IN, United States of America

William F Moore