Smithkline Beckman Corporation

Smithkline Beecham Corporation

Smithkline Corporation

Affinium Pharmaceuticals, Inc.

Smithkline Beechman Corporation

William F Huffman

James Francis Callahan

Kenneth Allen Newlander

Michael L Moore

Nelson C Yim

William Edward Bondinell

Richard McCulloch Keenan

John G Gleason

Kenneth G Holden

Fadia E Ali

William Henry Miller

Irene Nijole Uzinskas

Mark Andrew Seefeld

Thomas Wen-Fu Ku

Dalia R Jakas

Walter J Burgess

Pradip Kumar Bhatnagar

James Martin Samanen

Brian W Metcalf

James E Talmadge

James W Wilson

Tobias Oregon Yellin

Ralph Floyd Hall

Garland R Marshall

Chet Kwon

Thomas The Nguyen

M Amparo Lago

William M Bryan

Dennis T Takata

Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.

Fab I inhibitors

Bicyclic fibrinogen antagonists

Cyclic penta- and hexa-peptide libraries containing one or more known amino acids, one or more randomized amino acids and a conformationally constraining element are disclosed. These peptide libraries may be used for screening for new bioactive peptides and for elucidating structural information pertinent to drug design.

Cyclic semi-random peptide libraries

Compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form a seven-membered ring containing one optionally substituted nitrogen atom and one heteroatom selected from oxygen and nitrogen;

Platelet aggregation inhibiting compounds

Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist

Compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form a seven-membered ring containing one optionally substituted nitrogen atom;

The invention provides compounds of the general formula: ##STR1## The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.

Hemoregulatory peptides

Growing community of inventors

Malvern, PA, United States of America

William F Huffman