Georgetown University

Research, Incorporated

William F Feller

Jack G Chirikjian

Terence M Phillips

A method for detecting an antigen in a plasma or serum sample, which comprises conditioning the sample, wherein conditioning comprises either diluting the sample by a factor of at least 100 or dissociating the antigen in the sample from binding proteins with acid, base, or a chaotropic agent; drying the conditioned sampled; and detecting the antigen in the dried sample using an immunological assay is disclosed. The method is particularly useful for the detection of antigens associated with breast cancer.

Breast cancer diagnostic blood test

A method for diagnosing mammalian breast cancer by detecting in the physiological fluid of said mammal an antigen (ACRT) having immune cross-reactivity with human reverse transcriptase, or detecting antibodies against said ACRT or detecting antibody-ACRT complexes, wherein the reverse transcriptase is substantially purified, has a molecular of about 70,000 and a sedimentation coefficient on a glycerol gradient of between 5 and 5.5 S. A process for the purification of reverse transcriptase from human milk.

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Bethesda, MD, United States of America

William F Feller