Eli Lilly and Company

William Ernest Alborn, Jr

Paul Luther Skatrud

Larry C Blaszczak

Scott C Mauldin

JoAnn Hoskins

Mohammad Sadegh Zia-Ebrahimi

Michael Scott VanNieuwenhze

Serhat Unal

A process is described for preparing a substrate for the transglycosylase enzymes of bacterial cell wall biosynthesis. The chemical synthesis makes available a sustainable and substantially pure source of supply of lipid II, including analogs thereof, that may be used in the identification of new therapeutic agents capable of disrupting steps in bacterial cell wall biosynthesis.

Process for preparing lipid II

The instant invention provides the femA gene of Staphylococcus epidermidis and all degenerate sequences thereof, the protein encoded by the femA gene (FemA), and vectors and microorganisms comprising genes encoding the FemA protein.

FemA gene of staphylococcus epidermidis, femA protein, and vectors and

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Carmel, IN, United States of America

William Ernest Alborn, Jr