Amsel Medical Corporation

Tyrx, Inc.

Paragonix Technologies, Inc.

C. R. Bard, Inc.

Misonix, Inc.

Medtronic, Inc.

St. Jude Medical, Inc.

Ambu A/s

Arrow International Limited

Highland Instruments, Inc.

William Edelman

Nir Lilach

Raanan A Miller

Arikha Moses

Fatima Buevich

Frank Do

Arnold Miller

William McJames

Mason Diamond

Satish K Pulapura

Jared Alden Judson

Lisa Maria Anderson

Shari Timothy

Robert R Andrews

Gerd Schmieta

Joseph A Levendusky

John C Brumbach

Ilyssa A Hunt

Robert L O'Brien

Timothy Andrew Wagner

Joseph F Brumbach

Kyungmin Andy Lee

Dennis L Hechel

John L Maynard

Omri Nave

Paul James Mulhauser

Avraham Ram Lore

Peter T Majeski

Laura Dipietro

Richard Pignatone

Charles Dandreta

William Mcjames

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers and/or non-tissue layers together by providing implantable elements on opposite sides of the structure or layers and drawing the implants together to occlude the body structure and/or bring the layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture.

Methods and apparatus for fastening and clamping tissue

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the anatomical structure to urge the layers together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture. The invention can be used to fasten tissue to non-tissue.

Methods and apparatus for clamping tissue and occluding tubular anatomical structures

Methods and devices for temporarily occluding blood vessels are provided for use in emergency conditions to control trauma-induced hemorrhaging. An occlusion device is delivered and deployed through a rapidly introduced, percutaneously placed needle that carries an occlusion device in readiness to be deployed out of the needle. The deployed occlusion device applies pressure to the target blood vessel to control blood loss.

Apparatus and method for temporary occlusion of blood vessels

Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially lung tissue, through the use of an expandable accumulator to maintain a constant pressure within the lumen of the organ even during external pressure fluctuations due to, for example, flight. Systems and methods may include prolonging donor organ viability in storage through the use of an organ container that mimics the geometry and orientation of the organ in vivo.

Apparatus for tissue transport and preservation

Method and apparatus for delivering multiple tissue fasteners with needle and fastener assemblies each of which comprises a hollow needle adapted to be passed through tissue layers to be fastened, the needle containing a proximal and a distal implant, the implants being configured to self-expand when ejected from the needle, the implants being lockable to each other after ejection in response to drawing the implants together with tissue gripped between the implants.

Method and apparatus for delivering multiple tissue fasteners

Apparatus and methods are provided for occluding blood vessels and other anatomical structures. Occlusion devices are delivered percutaneously and extraluminally through a small gauge needle and include expandable elements that are deployable on opposite sides of a target vessel to be occluded. When positioned about the vessel the elements are expanded and brought together to compress and occlude the vessel. Embodiments include those adapted for temporary as well as permanent use.

Apparatus and methods for occlusion of blood vessels

Methods and apparatus are provided for fastening or clamping tissue to tissue or non-tissue layers and for occluding tubular body structures. Tissue fasteners having separate proximal and distal implants, each with self-expanding, radially extending legs are connected together on opposite sides of tissue and non-tissue layers. The legs of the proximal and distal implants are interdigitated in the absence of such layers.

The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.

Temporarily stiffened mesh prostheses

A method for intubation of a patient comprising: providing an LMA and an endotracheal tube, wherein the endotracheal tube comprises a visualization device and wherein the endotracheal tube is adapted for passing through the LMA; positioning the LMA in the patient; and guiding the endotracheal tube with the aid of the visualization device through the LMA for positioning in the trachea of the patient. The method preferably further comprises removing the LMA from the patient following the positioning of the endotracheal tube while leaving the endotracheal tube in position.

Endotracheal tube with visualization capabilities and a laryngeal mask

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture.

Method and apparatus for clamping tissue layers and occluding tubular body structures

Transporter for a tissue transport system

A system for occluding a hollow structure, the system comprising: a plurality of occluders; and an applicator for storing the plurality of occluders and serially delivering the occluders so as to occlude the hollow structure.

Apparatus and methods for fastening tissue layers together with multiple tissue fasteners

Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.

Resorbable pouches for implantable medical devices

Growing community of inventors

Sharon, MA, United States of America

William Edelman