The Procter Gamble Company

William E Snyder

Gerald B Kasting

Ronald L Smith

Ellen R Massaro

Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C.sub.3 -C.sub.4 diol or C.sub.3 -C.sub.6 triol and isocetyl alcohol polar lipid compound. The vehicle provides marked transepidermal and percutaneous delivery of the iminopyrimidine compound. These compositions, when applied topically, act to stimulate the growth of mammalian hair on the body.

Penetrating topical pharmaceutical compositions

A mild skin-cleansing, nonlathering mousse-forming emulsion which leaves the skin, after washing, feeling moisturized, soft and smooth, and which does not require rinsing. The emulsion comprises:

Nonlathering cleansing mousse with skin conditioning benefits

A synergistic skin conditioning emulsion composition comprising a fatty acid or a mixture of fatty acids, a polysiloxane fluid, a water-soluble polymer and water. The fatty acids, the polysiloxane and the water-soluble polymer combine to form a water-resistant barrier which allows skin to stay in a smooth and supple condition for an extended period of time.

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Cincinnati, OH, United States of America

William E Snyder