Integrated Dna Technologies, Inc.

William E Martin, Iii

Shawn Allen

Joseph Alan Walder

Jeffrey A Manthey

Shawn Walsh

Yakov A Letuchy

Kye Roth

David W Muller

Disclosed herein are nucleic acid-based data storage systems and nucleic acid data storage constructs comprising reusable nucleic acid sequences, each representing information carried by a single bit (and, in some embodiments, one or more adjacent bits) within a bit string, and each furthermore representing the position of the single bit within the bit string. Also described are methods for storing data in the nucleic acid-based data storage systems and nucleic acid data storage constructs of the disclosure.

DNA data storage using reusable nucleic acids

This disclosure provides methods of manufacturing a controlled pore glass, including: (a) adding an acidic solution to a column containing borosilicate glass; (b) flushing the column from step (a) with an aqueous solution until the pH of the effluent is greater than about 6; (c) adding a basic solution to the column from step (b); and (d) flushing the column from step (c) with an aqueous solution until the pH of the effluent is less than about 9 to produce a controlled pore glass.

Method of making controlled pore glass

The disclosed invention pertains to improved oligonucleotide manufacturing methods, including novel support compositions that are optionally labeled, their methods of preparation and use. The compositions and methods are particularly well suited for high throughput oligonucleotide manufacturing in that the automated support recognition facilitates loading of the wells with the proper supports. In addition, the labeled supports can be used to confirm that each well of a multi-well plate, such as a 96 or 384 well plate, was properly loaded.

Labeled solid supports for organic synthesis

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Coralville, IA, United States of America

William E Martin, Iii