Mallinckrodt, Inc.

William E Dummitt

Henry J Buehler

Anthony Mannino

Hong Gu

Dennis C Aubuchon

Douglas C Caskey

Brian Orr

Ervin B Inskip

The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of &#x3b1;,&#x3b2;-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A) 

Process for preparing morphinan-6-one products with low levels of &#x3b1;,&#x3b2;-unsaturated ketone compounds

The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of &#x3b1;,&#x3b2;-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.

Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds

The present disclosure generally relates to methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydromorphone, hydrocodone, or a derivative thereof, by means of a non-catalytic hydrogenation reaction of thebaine, oripavine or a derivative thereof, respectively, using a hydrazide reagent, followed by hydrolysis of the hydrogenated intermediate at a low temperature and for a short period of time. Additionally, the present disclosure relates to a composition comprising the desired hydromorphone, hydrocodone, or a derivative thereof, in combination with a 6-beta compound that is structurally related thereto.

Methods for producing hydrocodone, hydromorphone or a derivative thereof

An improved method for preparing 4,4' difluorobiphenyl by reacting a parafluorinated Grignard reagent and a parafluorinated halophenyl in solution and in the presence of free palladium producing catalysts is disclosed.

Method for preparing 4,4' difluorobiphenyl

Disclosed is a process for inhibiting polymerization of polymerizable ethylenically unsaturated monomers such as hydrocarbons, acids and esters, wherein manganese nitrite, i.e. Mn(NO.sub.2).sub.2, is employed as an inhibitor. A composition including a polymerizable ethylenically unsaturated monomer and Mn(NO.sub.2).sub.2 is also disclosed. In two preferred embodiments, acrylic acid and styrene, respectively, are the monomers.

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St. Louis, MO, United States of America

William E Dummitt