Becton Dickinson and Company Limited

Sicpa Holding Sa

Emory University

Cabot Security Materials, Inc.

William E Doering

Michael J Natan

Ian Walton

Marcelo Eduardo Piotti

Richard Griffith Freeman

Shuming Nie

Remy Cromer

Felicia Tam

Rebecca Stoermer Golightly

Sharron Gaynor Penn

R Griffith Freeman

Gabriela Chakarova

Richard D Freeman

Michael Sha

Hongxia Xu

Gabriela S Chakarova

Sharron Penn

R Freeman Griffith

Peter Corish

Materials and objects tagged with wavelength selective particles such as SERS nanotags modified for wavelength selectivity. As used herein, a wavelength selective particle is one which cannot be effectively excited or interrogated at one or more wavelengths where a reporter molecule associated with the particle would normally produce a spectrum. Also disclosed are methods of manufacturing wavelength selective particles and methods of tagging materials or objects with wavelength selective particles.

Wavelength selective SERS nanotags

An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.

Inline spectroscopic reader and methods

Embodiments include a particle comprising a surface enhanced spectroscopy (SES)-active core and a SES-active reporter molecule associated with the SES-active core wherein said particle has a measurable SES spectrum when excited by incident light having a wavelength of at least 1400 nm. Alternative embodiments include methods of manufacturing said particle and methods of tagging a material with said particle. The particle may include an SES-active core which supports plasmon resonance at a wavelength of at least 1400 nm. The particle may comprise an anisotropic core. The particle may include an SES-active reporter molecule which is resonant at one or more wavelengths greater than or equal to 1400 nm.

Particles comprising hollow surface-enhanced spectroscopy (SES)-active core for long wavelength SERS

Various methods of use for surface enhanced spectroscopy-active composite nanoparticles (SACN's) are provided. SACN's are submicron-sized particles or labels can be covalently or non-covalently affixed to entities of interest for the purpose of quantification, location, identification, tracking, and diagnosis. The various methods include administering a SACN nanoparticle imaging agent to a patient, scanning the patient using a system that can perform spectral imaging; and generating a spectrum or image of an internal region of the patient. A method, for diagnosing an abnormal pathology as well as a method for labeling an animal with a SACN are also provided.

Methods of use for surface enhanced spectroscopy-active composite nanoparticles

A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.

Melamine assay methods and systems

Surface Enhanced Spectroscopy-Active Composite Nanoparticles (SACN) comprising: core/shell nanoparticles comprising nanoparticle cores covered with shells, wherein the cores and the shells may comprise the same or different materials; at least one Raman-active reporter molecule associated with said core/shell nanoparticle; and an SiOencapsulant which encapsulates the core/shell nanoparticle and the at least one Raman-active reporter molecule, are described.

Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules

An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.

Polymer coated SERS nanotag

Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among others, includes a surface-enhanced Raman spectroscopic active composite nanostructure. The surface-enhanced Raman spectroscopic active composite nanostructure includes a core, at least one reporter molecule, and an encapsulating material. The reporter molecule is bonded to the core. The reporter molecule is selected from: an isothiocyanate dye, a multi-sulfur organic dye, a multi-heterosulfur organic dye, a benzotriazole dye, and combinations thereof. The encapsulating material is disposed over the core and the reporter molecule. After encapsulation with the encapsulating material, the reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.

Growing community of inventors

Mountain View, CA, United States of America

William E Doering