The Procter Gamble Company

Micropure, Inc.

William E Cooley

James L Ratcliff

Jaiprakash G Shewale

Esmeralda Ann Garcia-Smith

Esmeralda Ann Garcia

Francis O Agricola

Jessica Ward Dykstra

Lee E Kirsch

Gary Armitage

Karen Black

Robert Ashley

Described herein are single-phase compositions and methods for its pharmaceutical and cosmetic use, comprising (i) a combination of N-acyl sarcosinate, (ii) an oxidative compound, and (iii) a buffering system in amounts and embodiments effective to protect the oxidative compounds from degradation prior to use and upon use and to enhance the efficacy of the composition in removing polymicrobial biofilms, reducing the re-growth of polymicrobial biofilms that leads to plaque formation, greater availability of chlorite ion for antimicrobial and cosmetic purposes, and effective oxidation of salivary biomolecules. When these single-phase compositions are comprised of a source of fluoride ion, they also achieve enhanced enamel fluoride uptake, higher enamel protection by enhanced remineralization and reduced demineralization of teeth when compared to US Pharmacopoeia Reference Dentifrice, prior known toothpastes comprising stabilized chlorine dioxide and comparable commercial dentifrices.

N-acyl sarcosinate compounds and oxidative compounds with improved stability and efficacy for use in pharmaceutical compositions

Some embodiments described herein provide for a multi-component compositions and methods for its pharmaceutical and cosmetic use, comprising a combination of an aliphatic anionic compound, an oxidative compound, and a buffering system. Source of fluoride ion and other carriers are optional ingredients. The aliphatic anionic compound and the oxidative compound function together, in presence or absence of fluoride ion source, to protect the oxidative compounds from degradation prior to use and upon use, and to enhance the efficacy of the composition. In addition to achieving greater stability, combined effects of the aliphatic anionic compound, oxidative compound and source of fluoride ion achieve enhanced fluoride uptake, higher enamel protection by enhanced remineralization and reduced demineralization, increased plaque removal, reduced re-growth of plaque polymicrobial biofilm, greater amount of chlorite ion availability and effective oxidation of salivary biomolecules.

Aliphatic anionic compounds and oxidative compounds with improved stability and efficacy for use in pharmaceutical compositions

Oral compositions, such as toothpastes, mouthwashes, lozenges and chewing gum, containing a chlorous acid liberating material, and an antidemineralization agent such as indium are disclosed.

Oral compositions

Anticariogenic oral compositions such as dentifrices and mouthwashes comprising a water-soluble fluoride salt and an indium (III)-malic acid water-soluble complex as a stable and dental enamel reactive source of indium.

Oral compositions for caries prophylaxis

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Wyoming, OH, United States of America

William E Cooley