Agilent Technologies, Inc.

William E Barber

Wu Chen

Ta-Chen Wei

Mark A Nickerson

Timothy J Langlois

Frank Marsden Willis

Alan D Broske

Charles Lofton

Superficially porous hybrid particles include hybrid solid cores that each contain an inorganic material and an organic material; and porous hybrid outer shells each include the inorganic and organic materials and having ordered pores, wherein the ordered pores have a median pore size ranges from about 15 to about 1000 &#x212b; with a pore size distribution (one standard deviation) of no more than 50% of the median pore size and produce at least one X-ray diffraction peak between 0.01&#xb0; and 10&#xb0; of a 2&#x3b8; scan range; wherein the particles have a median size range from about 0.5 &#x3bc;m to about 100 &#x3bc;m with a particle size distribution (one standard deviation) of no more than 15% of the median particle size, wherein the inorganic material comprises a metal oxide selected from silica, alumina, titania or zirconia.

Superficially porous metal oxide particles, methods for making them, and separation devices using them

A column for use in chromatography, the column having a tube with a bore that can contain a packing medium captured between two porous plugs positioned at opposite ends. End fittings are attached to the tube ends, the end fittings having a duct with a duct opening having a diameter at least as large as the diameter of the tube bore which it faces. The duct opening may be positioned within a recess in spaced apart relation to the porous plugs to prevent the end fitting from contacting the plug and burnishing its surface.

Chromatography column with large diameter end fitting openings

The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation.

Inorganic/organic hybrid totally porous metal oxide particles, methods for making them and separation devices using them

Micelle-templated superficially porous particles having a solid core and an outer porous shell with ordered pore structures and a narrow particle size distribution, such as about &#xb1;5% (one sigma), and a high specific surface area of about 5 to about 1000 m/g.

A process for producing a chromatographic stationary phase for use in reversed-phase chromatography. Chromatographic stationary phases prepared according to the methods of the current invention and liquid chromatography columns, which include the stationary phases, are also provided.

Reversed endcapping and bonding of chromatographic stationary phases using hydrosilanes

The invention provides novel compositions, columns and methods for improved chromatographic separations. In particular, novel column packings are provided to improve overall chromatographic separation and efficiency. The invention provides a packing material having particles or mixtures of particles that are used for separation of small molecules, proteins or nucleic acids.

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Landenberg, PA, United States of America

William E Barber