University of Texas System

Other

William E Allen

Jonathan L Sessler

Andrei Andrievsky

Petra I Sansom

Philip A Gale

Vincent Lynch

Christopher T Brown

Andreas Gebauer

Vladimir A Kral

Vladim&iacute;r A Kr&aacute;l

John W Genge

Vladimír A Král

The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neutral molecule-binding agents forming supramolecular ensembles, and ion- and neutral molecule-separation agents. The macrocycles are fully meso-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known but not recognized as possessing anion- or molecule-binding properties. The binding mode is noncovalent, primarily that of hydrogen-bonding, thereby providing a new mode for liquid chromatography, that of Hydrogen Bonding Liquid Chromatography. Further useful applications of the macrocycles provided herein include environmental remediation by removal of undesired ions or neutral molecules, and removal of phosphate for kidney dialysis.

Calixpyrroles

Calixpyrroles, calixpyridinopyrroles and calixpyridines

The present invention is directed to highly boronated derivatives of expanded porphyrins including sapphyrins and texaphyrins, and more particularly to expanded porphyrins substituted with carborane clusters. Such compositions are useful in boron neutron capture therapy, radiation therapy, photodynamic therapy, and other applications.

Highly boronated derivatives of texaphyrins

Growing community of inventors

Austin, TX, United States of America

William E Allen