Isp Investments Inc.

William Drefko

Rama K Haldar

James P Cullen

Edward G Malawer

Laurence Senak

Chi-San Wu

Antonio Moroni

Sidney Etienne

Dipan B Ray

David K Hood

Nadhamuni G Nerella

John N Zamora

Greg Dubrowny

Peter J Brush

Rama Haldar

Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10&#xb0; C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.

Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability

A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.

Process and apparatus for forming agglomerates of a powder composition of an active and binder

What is described herein is an excipient for a pharmaceutical tablet which is a proliferous copolymer of vinyl pyrrolidone and vinyl acetate, to provide the tablet with rapid dissolution and disintegration properties, and, also reduced hygroscopicity.

Proliferous copolymer of vinyl pyrrolidone and vinyl acetate

What is described herein is a pharmaceutical excipient which is a proliferous copolymer of vinyl pyrrolidone and vinyl acetate, having advantageous dissolution and disintegration properties.

A tablet coating composition including a mixture of (a) sodium alginate and (b) a polyvinylpyrrolidone-vinyl acetate copolymer, and, optionally, (c) hydroxypropylmethyl cellulose, and/or hydroxypropyl cellulose.

Tablet coating composition

A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament.

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Kearny, NJ, United States of America

William Drefko