Lilly Industries, Inc.

William Dawson

Colin W Smith

Michael John Foulis

Norman James Gutteridge

The invention relates to a method for the prophylactic or therapeutic treatment of an immediate hypersensitivity disease, which comprises administering to a mammal, including a human, a compound of the following formula ##STR1## in which the group --CHR.sup.1 R.sup.2 is in the 5- or 6- position of the benzoxazole nucleus, R.sup.1 is hydrogen or C.sub.1-4 alkyl, R.sup.2 is selected from the group --COOH or a salt or ester thereof, the group --CONH.sub.2 and the group --CH.sub.2 OH, and in which R.sup.4 is a phenyl group optionally substituted by one or two groups selected from halogen, C.sub.1-4 alkoxy, C.sub.1-4 alkyl and C.sub.1-4 haloalkyl, or optionally substituted in two adjacent positions by methylenedioxy.

Method of treating hypersensitivity disease with benzoxazole derivatives

Propanoic acid derivatives of the formula: ##STR1## where R.sup.1 is a C.sub.1-8 alkyl group optionally substituted by hydroxyl or --COOH and R.sup.2 is hydrogen or a protecting group, are useful as anti-thrombotic agents.

Cyclopentone propanoic acid compounds

The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-p ropanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(.beta.-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.

3-Substituted propanoic acid derivatives

Propanoic acid derivatives of formula: ##STR1## where X represents a ketonic or hydroxylic function, R.sup.1 is a C.sub.1.sub.-8 alkyl group optionally substituted by hydroxy or --COOH and R.sup.2 is hydrogen or a protecting group, having spasmolytic activity.

Organic derivatives

The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-propanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(.beta.-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.

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Camberley, United Kingdom

William Dawson