Wisys Technology Foundation, Inc.

Novascan, Inc.

William David Gregory

Christopher William Gregory

John W Shell

Moshe Morrie Altmejd

Paul Richard Voith

A method for characterizing tissues within a subject as cancerous or non-cancerous includes determining the electrical properties of the subject. The electrical properties of the subject are fit to a model and a specific range of a set of characteristic frequencies of each tissue is then calculated. Each tissue is finally characterized as cancerous or non-cancerous if the specific range of the set of characteristic frequencies inside or outside, respectively, a pre-determined spread of characteristic frequencies.

Method for detecting both pre-cancerous and cancerous tissues

One embodiment of the present application sets forth a method for detecting cancerous cells in a sample of excised tissue. The method includes a first subset of electrodes included in an electrode array measuring, at a first operating frequency, a first impedance of a first section of the sample. The method also includes computing a first Cole relaxation frequency for the first section of the sample based on the first impedance. The method also includes determining that the first section of the sample contains cancerous cells based on the first Cole relaxation frequency.

Techniques for detecting cancerous cells in excised tissue samples using impedance detection

One embodiment of the present application sets forth a method for predicting recurrence of cancerous cells in a patient that includes measuring, by a first subset of electrodes included in an electrode array operating at a first frequency, a first impedance of a first section of a first sample of tissue excised from the patient, computing a first Cole relaxation frequency for the first section of the first sample based on the first impedance, and generating a first prediction relating to cancerous cells in the patient based at least in part on the first Cole relaxation frequency.

Techniques for predicting recurrence of cancerous cells using impedance detection

A system and method for detecting cancerous tissue in a subject is provided. More specifically, the present invention provides a system and method for non-invasively identifying cancerous regions in breast tissue. The system includes a sensor system, a drive system, and a processor. The sensor system includes a sensor plate and, similarly, the drive system includes a drive plate. A time-varying voltage is applied to the drive plate and induced currents are subsequently measured by the sensor plate. Signals indicative of an induced current are then acquired and analyzed by the processor to determine the spatial location of anomalous regions. Subsequently, the anomalous regions are characterized as either cancerous or non-cancerous.

System and method for early breast cancer detection using electrical property enhanced tomography

A device and method for accurately characterizing tissue impedance employs multiple electrodes at a plurality of separation distances to cancel the effects of front end loading leakage currents and electrode polarization to improve the accuracy of sensitive impedance measurements used to identify cancerous tissues. These measurements may be automated over a range of frequencies.

Method and apparatus for eliminating loading and electrode polarization effects in impedance measurements for tissues and electrolytes

A method for characterizing tissues within a subject as cancerous or non-cancerous includes determining the electrical properties of the subject. The electrical properties of the subject are fit to a model and a characteristic frequency of each tissue is then calculated. Each tissue is finally characterized as cancerous or non-cancerous if its characteristic frequency lies above a threshold value.

A device for characterizing ex vivo tissue employs a set of independent electrodes that may be used to scan the tissue by moving a voltage gradient across the tissue surface acquiring impedance spectrographs that may be mapped to an image.

Apparatus and method for evaluating ex vivo tissue samples by electrical impedance

An electrical parameter imaging apparatus and method includes the acquisition of a charge distribution pattern on an array of electrodes that surround an object being imaged. In addition the exterior boundary, or contours of the object is measured by an array of light beams and associated light sensors. The contour measurement is employed to provide a first estimate of the object geometry needed to compute an electrical parameter image from the acquired charge distribution pattern.

Method and apparatus for producing an electrical property image of substantially homogeneous objects containing inhomogeneities

An electrical property imaging system includes an array of sensors placed around an object to measure the surface charges thereon as a sinusoidal voltage is applied thereacross. The resulting distribution of charges inside the object are calculated using a stored charge correlation matrix. Electrical property images are produced from the internal charge distribution image.

Method and apparatus for producing an electrical property image using a charge correlation matrix

Enhanced information on the electrical properties of the subregions of a sample is generated by an enhanced tomography (EPET) apparatus connected to a tomographic device, wherein the EPET apparatus holds a voltage constant and measures the electrical current of the sample inserted within the EPET apparatus. A matching medium is applied to the sample such that when the sample is placed within an electromagnetic field generated by the EPET apparatus, the matching medium contacts the segmented sensor plates of the EPET apparatus and allows the detection of the net total charges Q on the surface of the sample. The EPET apparatus uses these net total charges Q in the calculation of the additional information on the electrical properties of the sample by using the scale factor method or the iterative correction method. The EPET apparatus and method has application in the medical imaging field, such as in the obtaining of enhanced dielectric constant and conductivity electrical properties values related to the imaging of the interior of the human body, e.g., in the determination of whether tissue is cancerous, dead or healthy.

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Shorewood, WI, United States of America

William David Gregory