Neurosearch A/s

Abarceo Ab

William Dalby Brown

Lene Teuber

Elsebet Østergaard Nielsen

Philip K Ahring

Janus Schreiber Larsen

Naheed Mirza

David Tristram Brown

Palle Christophersen

Alex Haahr Gouliaev

Bjarne H Dahl

Dorte Strøbæk

Joachim Demnitz

Frank Wätjen

Mads P G Korsgaard

Carsten Jessen

Kristian Tage Hansen Hansen

Sebastian Albert Salehi

This invention provides 2,3-diamino-quinazolinone compounds of Formula (I) stereoisomers thereof, pharmaceutically-acceptable addition salts thereof, and N-oxides thereof, wherein the variables are as defined in the specification. The 2,3-diamino-quinazolinone compounds have medical utility. The 2,3-diamino-quinazolinone compounds can be used for the manufacture of medicaments, including pharmaceutical compositions. This invention also provides methods of treating disorders, diseases, or conditions which are responsive to activation of K7 channels.

2, 3-diamino-quinazolinone derivatives and their medical use

This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAreceptor complex, and in particular for combating anxiety and related diseases.

Imidazole derivatives for the treatment of anxiety and related diseases

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This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are of the general formula (I) and include any of its stereoisomers, any mixture of its stereoisomers, and pharmaceutically acceptable salts thereof. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAreceptor complex, and in particular for combating anxiety and related diseases. 

This invention relates to novel compounds useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.

KCNQ channel modulating compounds and their pharmaceutical use

The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives.

Method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives

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Søborg, Denmark

William Dalby Brown