Wake Forest University

William D Wagner

Louis Charles Argenta

Michael J Morykwas

Nicole Hope Levi

David Loren Carroll

Jie Jerry Liu

Stephen Tatter

Jie Liu

Nicole H Levi

James Eric Jordan

Lawrence Xavier Webb

Thomas L Smith

J Baxter Mcguirt

Manoj Namboothiry

Nichole H Levi

Brian Werner

Faith M Coldren

Tabitha Rosenbalm

Rui Wang

James E Jordan

David L Carroll

Louis C Argenta

The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.

Devices and methods for treating spinal cord tissue

Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.

Nanofiber-based graft for heart valve replacement and methods of using the same

A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.

Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage

A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.

Conduit for peripheral nerve replacement

The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.

Small-scale pressure sensors

The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.

Device and method for treating central nervous system pathology

The present invention relates to the use of heparan sulfate, or a biological equivalent thereof, to regulate nucleic acid expression, expression of cell receptors, and infection by hepatitis B virus.

Regulation of nucleic acid expression by heparan sulfate and biological equivalents thereof

Growing community of inventors

Clemmons, NC, United States of America

William D Wagner