University of Virginia Patent Foundation

Uva Patent Foundation

William D Steers

Jeremy B Tuttle

The instant invention discloses a method of treating hyperactive voiding associated with excessive nerve growth factor production and nerve growth in patients by administering a Ca.sup.++ channel blocker. The Ca.sup.++ channel blockers verapamil and diltiazem can be administered systemically to treat hyperactive voiding, such as is associated with benign prostatic hyperplasia and interstitial cystitis.

Method of treating hyperactive voiding with calcium channel blockers

The method of detecting lower urinary tract disease is disclosed through the comparison of the concentration of a neurotrophic factor present in a urine specimen in comparison with a predetermined normal concentration. Nerve growth factor, having a concentration of approximately less than 8 picograms per milliliter is the preferred factor. The concentration of nerve growth factor in the urine rises at the onset of the lower urinary tract disease and decreases as said disease progresses. Nerve growth factor production and nerve growth is inhibited by administering the Ca.sup.++ channel blockers, verapamil or diltiazem.

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Charlottesville, VA, United States of America

William D Steers