University of Kansas

Oklahoma State University

William D Picking

Wendy L Picking

Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidalserovars. Methods of immunization comprise the use of the antigenic molecules.

Use of thespp type III secretion proteins as a protective vaccination

Disclosed are compositions comprising a Gram negative needle tip protein and a translocator protein and methods of their use.

Methods and compositions related to the next generation vaccine

Use of the salmonella SPP type III secretion proteins as a protective vaccination

Disclosed are methods and compositions related to polypeptides comprising a fusion of the needle tip protein and translocator protein of a type III secretion apparatus (T3SA) from a type III secretion system (T3SS) of a Gram negative bacteria. Disclosed herein are fusion polypeptides comprising a fusion of a needle tip protein, such as, Bsp22, LcrV, BipD, PcrV, CT053, or CT668, or anantigenic fragment thereof; and a translocator protein, such as, BopB, YopB, BipB, PopB, CopB, or CopB2, or anantigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria, such as,, or

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Broad-based, cross-protective, O-serotype independent vaccines againstand related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS) apparatus needle proteins IpaD and IpaB, and/or the IpaB cognate chaperone protein IpgC. Chimeric proteins of IpaD and IpaB, and/or IpgC are also encompassed.

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Lawrence, KS, United States of America

William D Picking