Electrophoretics Limited

International Flavors & Fragrances Inc.

Evolva Sa

William D O Hamilton

Joseph M Sheridan

Jonathan R Heal

Ian Hugo Pike

Esben Halkjaer Hansen

Joergen Hansen

Honey Polur

Karsten Kuhn

Stefan Kienle

Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.

Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside

The present invention provides 2-Methyl-amino-3-[(4-fluorophenyl)carbonyl]indolizine-1-carboxamide of formula (I) or a pharmaceutically acceptable salt thereof; and its therapeutic uses in the treatment of neurodegenerative disorders, in particular tauopathies and most preferably in the treatment of Alzheimer's disease.

Casein kinase 1 delta inhibitor

Compositions and methods for the biosynthesis of vanillan or vanillin beta-D-glucoside

The invention relates to pharmaceutical compositions having casein kinase 1 delta (CK1&#x3b4;) inhibitors and to the use of the inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.

Casein kinase 1&#x3b4; (CK 1&#x3b4;) inhibitors

Casein kinase 1delta (CK1delta) inhibitors

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Royston, United Kingdom

William D O Hamilton