Cognosci, Incorporated

Duke University

William D Matthew

Daniel T Laskowitz

Michael McMillian

Warren J Strittmatter

Catherine R Gutman

Eva S Anton

Marcia J Riggott

Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.

Methods of suppressing microglial activation

Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. ApoE receptor binding peptides that may be used in the methods of the invention are also described, as are methods of using such peptides to treat peripheral inflammatory conditions such as sepsis. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.

Methods of suppressing microglial activation and systemic inflammatory responses

The present invention relates, in general, to a method of producing a therapeutic effect and, in particular, to a method of using antibodies to promote cellular function, to antibodies suitable for use in such a method and to compositions comprising same.

Method of promoting cellular function

Provided herein are compositions comprising complexes of apolipoprotein E and ciliary neurotrophic factor. The apolipoprotein E can be any isoform, but is preferably apolipoprotein E3. Also preferred are covalent complexes of apolipoprotein E and ciliary neurotrophic factor, more preferably those formed by intermolecular disulfide bonds between cysteine residues. Further provided are methods of enhancing the survival of neural cells by administering a composition comprising a complex of apolipoprotein E and ciliary neurotrophic factor. The claimed methods can be carried out both in vitro and in vivo.

Complexes of apolipoprotein E and ciliary neurotrophic factor (CNTF) and methods of use

Peritoneal fluid and peritoneal wash fluid provide a source of abundant apolipoprotein E. Methods for isolating apolipoprotein E from peritoneal fluid or peritoneal wash fluid are provided.

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Durham, NC, United States of America

William D Matthew