Georgia Tech Research Corporation

P.j. Edmonson Ltd.

Other

Honeywell Federal Manufacturing & Technologies, LLC

Medical College of Georgia Research Institute, Inc.

Emory University

William D Hunt

Peter J Edmonson

Desmond D Stubbs

Kyle Spencer Davis

Kevin F Brennan

John Alexander Herrmann

Michelle LaPlaca

Farasat Munir

Chris Ward

Christopher D Corso

Adam Wathen

Michael Z Sleva

Colin K Campbell

James Geoffrey Maloney

Christopher J Summers

Marie E Csete

Amy Charlene Wilson

Paul W Doetsch

Ryan Sloan Westafer

Aaron S Green

Sang Hun Lee

Stephen T Makk

Anthony J Dickherber

Ronald D Briggs

David M Connuck

Elaine Rhoades

Anthony Dickherber

Dong Moon Shin

Carlos Sanchez Moreno

Georgia Zhuo Chen

Disclosed herein are methods of disrupting cell-to-cell communication. An exemplary method comprises transmitting one or more microwave signals to a communication molecule located in an environment having a plurality of cells. The one or more microwave signals can comprise a first microwave signal and a second microwave signal. The first microwave signal can have a first frequency corresponding to frequency of a first peak in a microwave spectrum associated with rotational modes of the communication molecule. The second microwave signal can have a second frequency corresponding to a frequency of a second peak in the microwave spectrum associated with the rotational modes of the communication molecule.

Systems and methods for microwave jamming of molecular recognition

An exemplary embodiment of the present disclosure provides a detector configured to output a signal associated with one or more interactions with subatomic particles. The detector comprises a sensor comprising a first diode comprising first semiconductor material abutting a first metal and forming a first junction, wherein the sensor is configured to be exposed to subatomic particles and a voltage reference member configured to generate a reference measurement. The sensor and the voltage reference member form a bandgap reference circuit. The present disclosure also provides methods for detecting subatomic particles from a solid-state detector comprising a first Schottky diode in electrical communication with a reference voltage member comprising a parallel circuit of two or more second Schottky diodes, wherein the first Schottky diode is configured to be exposed to subatomic particles and the second Schottky diodes of the reference voltage member are configured to generate a reference measurement.

Semiconductor work function reference circuit for radiation detection

An electrostatic harvester device for charging an energy storage device is provided. The electrostatic harvester device comprises an inductor, a variable capacitor device, a semiconductor device, and a plurality of transistors. The inductor is operable to receive electric charge and store the electric charge. The variable capacitor device is configured to receive electric charge from the inductor and to change capacitance in response to physical stimulation. The semiconductor device is operable to allow electric current to flow from the variable capacitor device. The transistors are operable to connect at least two of the aforementioned devices. At least one of the transistors comprises at least one of gallium nitride or aluminum gallium nitride.

Electrostatic harvester device

Systems and methods include directing limited frequencies of microwave signals toward target molecules, driving a motion of the target molecules to impact molecular recognition. In one implementation, a microwave spectra associated with the rotational modes of a target molecule is obtained. From peaks in the spectra, a mode of molecular movement is identified and a microwave signal profile is generated for driving a motion of binding portions of the molecule associated with the identified mode. Microwave signals are generated based on the signal profile for output by antennas. For example, the microwave signals can be can be used to impede the binding of quorum sensing molecules by receptors of. In one implementation, the antennas can be placed in a catheter for placement in a patient. In another implementation, the antennas can be placed in a sleeve or other device for use adjacent to the skin of a patient.

A thin-film bulk acoustic wave delay line device providing true-time delays and a method of fabricating same. An exemplary device can comprise several thin-film layers including thin-film transducer layers, thin-film delay layers, and stacks of additional thin-film materials providing acoustic reflectors and matching networks. The layer material selection and layer thicknesses can be controlled to improve impedance matching between transducers and the various delay line materials. For example, the transducer layers and delay layers can comprise piezoelectric and amorphous forms of the same material. The layers can be deposited on a carrier substrate using standard techniques. The device can be configured so that mechanical waves propagate solely within the thin films, providing a substrate-independent device. The device, so constructed, can be of a small size, e.g. 40 &#x3bc;m per side, and capable of handling high power levels, potentially up to 20 dBm, with low insertion loss of approximately 3 dB.

Thin-film bulk acoustic wave delay line

The various embodiments of the present disclosure relate generally bulk-acoustic-wave resonators. An exemplary embodiment of the present invention provides a bulk-acoustic-wave resonator comprising an acoustic reflector, a substantially c-axis oriented hexagonal crystal structure, and a plurality of electrodes. The crystal structure is solidly-mounted to the acoustic reflector. The bulk-wave resonator resonates in at least two non-harmonically-related operational modes.

Multi-mode bulk-acoustic-wave resonators

An acoustic wave biosensor comprises a plurality of spaced apart electrodes disposed on a substrate of piezoelectric material and having a biolayer matched to a specific type of autoinducer signaling molecule to be detected. The biolayer comprises a layer of heterobifunctional molecules disposed on the electrodes and on the piezoelectric material between the electrodes, and a plurality of bioreceptor molecules which bind exclusively with the specific type of autoinducer signaling molecule to be detected. The bioreceptor molecules are supported by the layer of heterobifunctional molecules, and a hydrogel layer surrounds the bioreceptor molecules to support a three-dimensional structure thereof. The bioreceptor molecules can bind with the specific type of autoinducer signaling molecule to be detected, and the biolayer is reactive thereto such that corresponding autoinducer signaling molecules bind to the biolayer and detectably vary acoustic characteristics of the acoustic wave biosensor.

Acoustic wave biosensor for the detection and identification of characteristic signaling molecules in a biological medium

A biosensor for detecting particular substances biosensor comprises a piezoelectric material, an input transducer supported by the piezoelectric material to receive an input signal and propagate a corresponding acoustic wave within the piezoelectric material and an output transducer supported by the piezoelectric material to receive the acoustic wave. At least two chemically orthogonal or semi-orthogonal biolayers are supported by the piezoelectric material to receive substances to be tested and cause corresponding changes in the acoustic wave. The output transducer can transmit a corresponding output signal embodying separate channel data indicative of the substances received.

Differentiation and identification of analogous chemical and biological substances with biosensors

Acoustic wave devices coated with a biolayer are described for the detection target bio-molecules. The acoustic wave device is connected in an oscillator circuit, and the frequency shift &#x394;f resulting from a biomolecular event is recorded. Further described are the use of Rayleigh wave surface acoustic wave devices for vapor phase detection as well as quartz crystal microbalance devices for liquid phase measurements. A biofilm on the surface of the acoustic wave device comprises of a layer of antibodies raised against a specific target molecule or antigen. Signatures for detection events are presented in the form of frequency shifts &#x394;f(t).

Systems and methods for molecular recognition

An acoustic wave sensor assembly includes piezoelectric material, a first acoustic wave resonator element structure mounted on the piezoelectric material for interacting with an electrical signal, the acoustic wave resonator element structure being operable to interact with an acoustic wave propagating within the piezoelectric material to produce a first frequency response. Further acoustic wave resonator element structures are mounted on the piezoelectric material for interacting with electrical signals, the further acoustic wave resonator element structures being operable to interact with further acoustic waves propagating within the piezoelectric material to produce subsequent frequency responses. The first acoustic wave resonator element structure and further acoustic wave resonator element structures are combined to form a ladder or lattice filter network to produce an overall frequency response. Sensitive areas are mounted on the piezoelectric material and associated with the acoustic wave resonator element structures which, if predetermined effects to be sensed or detected are present, are modified thereby to control the nature of the frequency responses with resultant specific perturbations of the combined frequency response and thereby provide information with respect to the predetermined effects to be sensed or detected.

Acoustic wave sensor assembly utilizing a multi-element structure

A method of detecting and identifying bacteria, micro-organisms or plants in a liquid or gaseous medium, the bacteria, micro-organisms or plants being of the kind which produce signaling molecules in intercellular space, includes positioning a biosensor in the liquid or gaseous medium, the biosensor having a biolayer matched to specific signaling molecules to be detected whereby the biolayer is reactive thereto in a manner which varies operation of the sensor. Such variation of the operation of the biosensor is detected to thereby determine the presence and purpose of the bacteria, micro-organisms or plants in the liquid or gaseous medium.

An RFID biosensor detection system for detecting particular substances has an interrogator circuit to transmit a radio frequency signal, an input transducer mounted on a piezoelectric material to receive an input radio frequency signal and propagate a corresponding acoustic wave within the piezoelectric material. At least two chemically orthogonal or semi-orthogonal biolayers are mounted on the piezoelectric material to receive substances to be tested and cause corresponding changes in the acoustic wave. An output transducer is mounted on the piezoelectric material to receive the acoustic wave and transmit a corresponding output radio frequency signal. A receiver circuit receives the corresponding output radio frequency signal and provides separate channel data indicative of the substances received.

Differentiation and identification of analogous chemical or biological substances with biosensors

A sensing system includes an acoustic wave device comprising a body of piezoelectric material, and a first electrode assembly mounted on the piezoelectric body whereby an appropriate input applied to the electrode assembly produces an acoustic wave in the piezoelectric body and a first frequency response. The acoustic wave device also has a second electrode assembly to produce a second frequency response, the second electrode assembly being in contact with an area sensitive to a supplied stimulus to cause a characteristic of the sensitive area to change when a supplied stimulus is sensed to thereby change the second frequency response. The acoustic wave device has an output connected to the input of an amplifier, the amplifier having an output connected to the input of a coupling device. The coupling device is connected to the input of the acoustic wave device and has an output connected to a detector. The acoustic wave device, the amplifier and the coupling device are configured to be in an 'off' condition when no supplied stimulus is sensed by the sensitive area of the acoustic wave device and to be in an 'on' condition when a supplied stimulus is sensed by the sensitive area. The coupling device is configured to send a change signal to the detector when a change from the &#x201c;off&#x201d; condition to the &#x201c;on&#x201d; condition occurs.

Sensing systems utilizing acoustic wave devices

A biosensor detection system for detecting a particular substance has at least two biosensor devices. Each biosensor device includes a piezoelectric material, an input transducer mounted on the piezoelectric material to receive an input radio frequency signal and propagate a corresponding acoustic wave within the piezoelectric material and an output transducer mounted on the piezoelectric material to receive the acoustic wave and transmit a corresponding output radio frequency signal. A biolayer is mounted on the piezoelectric material to receive a substance to be tested and cause a corresponding change in the acoustic wave. An oscillator circuit is connected to the input transducer and to the output transducer, the oscillator circuit including an amplifier and providing an output signal indicative of a change in the acoustic wave. The biosensor devices having two different biolayers, whereby the output signals can be utilized to detect receipt of a particular substance by the biolayers of the biosensor devices.

Growing community of inventors

Decatur, GA, United States of America

William D Hunt