Alcon, Inc.

American Cyanamid Company

Alcon Laboratories, Inc.

Other

William D Dean

Raymond E Conrow

Michael E Deason

Pete Delgado

Michael S Gaines

Paul W Zinke

Anura P Dantanarayana

Steven J Sproull

David R Pierce

David N Ridge

Robert F Church

Greg Wickard

A flying decoy assembly that simulates the landing characteristics of waterfowl is provided. The simulated landing characteristics may include, but are not limited to, whiffling, gliding, floating, dipping, and/or flapping motions. The system generally comprises a waterfowl decoy pivotally interconnected to a stand. The decoy system can be used over water or in the field.

Waterfowl decoy system and apparatus

Methods of making indazoles are described. The methods involved reacting an aromatic aldehyde with a nitrogen source to form a nitroso aromatic aldehyde. The nitroso aromatic aldehyde is reacted with a reducing agent to form an indazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.

Methods of making indazoles

Novel processes useful in the preparation of 11-oxa prostaglandin analogs are disclosed.

Process for use in 11-oxa prostaglandin synthesis

Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.

Compounds for use in 11-oxa prostaglandin synthesis

Processes and novel intermediates for 11-oxa prostaglandin synthesis

Process for preparation of clonidine derivatives

A process for synthesizing carbonic anhydrase inhibitors is disclosed.

Preparation of carbonic anhydrase inhibitors

A process for making acrylmaleic acid and arylmaleic anhydride derivative useful as intermediates for the preparation of arylmaleimides in the synthesis of compounds having activity in the central nervous system. The process involves reacting arylacetonitriles with glyoxylic acid to provide novel intermediate 3-aryl-3-cyanopropeneoates which may be converted to the arylmaleic acid and arylmaleic anhydride derivatives.

Facile synthesis of arylmaleic acids and anhydrides

The invention provides a novel process for producing N-[3-(1H-imidazol-1-yl)phenyl]-4-(substituted)-2 pyrimidinamine compounds in which the substituent is a 2-pyridinyl, 3-pyrindinyl, 4-pyridinyl, 2-furanyl or 2-thienyl group. The process includes the steps of (1) reacting a 3-(1H-imidazol-1-yl)benzamine with cyanamide and a halogen acid while controlling the pH of the reaction between pH about 2 to abourt 3.5 and recovering a [3-(1H-imidazol-1-yl)phenyl] guanidine dihydrohalide and (2) reacting the [3-(1H-imidazol-1-yl)phenyl] guanidine dihydrohalide so recovered with an appropriately substituted 3-dimethylamino-1-(substituted)-2-propen-1-one and a base at a pH of from about 10.5 to about 11.5 and recovering the N-[3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidamine compound so produced. The novel process provides improved yield and purity by adhering to the stated crucial pH ranges.

Process for the synthesis of

An improved process for the large scale production of the compound (3.beta.,5.alpha.)-3-hydroxycholest-8(14)-en-15-one is described and two new compounds which have utility as intermediates in synthetic routes to the subject compound are disclosed.

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Arlington, TX, United States of America

William D Dean