Thrasos Innovation, Inc.

Thrasos Therapeutics Inc.

Thrasos, Inc.

Creative Biomolecules, Inc.

William D Carlson

Peter C Keck

Dattatreyamurty Bosukonda

Michael Sworin

Philippe Bey

Dattatreymurty Bosukonda

David C Rueger

Kuber T Sampath

Diana L Griffith

The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.

TDF-related compounds and analogs thereof

The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.

TDF-related compounds and analogs thereof, analogs and bioactive fragments

Single domain TDF-related compounds and analogs thereof for use in treating a tissue differentiation factor related disorder

Single domain TDF-related compounds and analogs thereof

The invention disclosed herein provides methods and compositions for the computer-assisted design of morphogen analogs. Practice of the invention is enabled by the use of at least a portion of the atomic co-ordinates defining the three-dimensional structure of human osteogenic protein-1 (hOP-1) as a starting point in the design of the morphogen analogs. In addition, the invention provides methods for producing morphogen analogs of interest, and methods for testing whether the resulting analogs mimic or agonize human OP-1-like biological activity. The invention also provides a family of morphogen analogs produced by such methods.

Computer system and methods for producing morphogen analogs of human OP-1

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Weston, MA, United States of America

William D Carlson