International Business Machines Corporation

William Clarence Swope

Julia Elizabeth Rice

Hans Werner Horn

Peter Martin Schwarz

Blake G Fitch

Michael C Pitman

Laura Myers Haas

Wolfgang Huber

Alan Ronald Bays

Brian John Cragun

Hoa Thu Tran

Robert Dennis Miller

Victoria A Piunova

Amphiphilic star polymers were prepared having superior loading properties for delivery of hydrophobic biologically active materials intended for use in medical, cosmetic, and other applications. The star polymers comprise a plurality block copolymer arms linked to a crosslinked polyester core. The monovalent arms comprise a peripheral poly(ethylene oxide) block (PEG block) and a polyester block, which is linked to the core. The sidechain substituents of the polyester block substantially improve the loading capacity of the star polymer for CoQ10 and other hydrophobic materials.

Polyester nanogel core star polymers for delivery of therapeutic agents

A field-based similarity search system includes an input device which inputs a query molecule, and a processor which partitions a conformational space of the query molecule into a fragment graph including an acyclic graph including plural fragment nodes connected by rotatable bond edges, computes a property field on fragment pairs of fragments of the query molecule from the fragment graph, the property field including a local approximation of a property field of the query molecule, constructs a set of features of the fragment pairs based on the property field, the features including a set of local, rotationally invariant, and moment-based descriptors generated from all conformations of the fragment graph of the query molecule, and weights the descriptors according to importance as perceived from a training set of descriptors to generate a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys.

Field-based similarity search system and method

Methods, systems, and articles of manufacture for indexing annotations made for a variety of different type (i.e., heterogeneous) data objects are provided. A set of parameters uniquely identifying an annotated data object may be converted to an index comprising a set of index values, each corresponding to a column in a homogeneous index table. In order to accommodate the indexing of heterogeneous data objects, a mapping may be provided for each different type (or classification) of data object that may be annotated, that defines how the identifying parameters of that type will be mapped to the columns of the homogeneous index table.

Heterogeneous multi-level extendable indexing for general purpose annotation systems

A method and apparatus for capturing annotations about database material in a way that allows queries with conditions or predicates on both the database material and the annotations. Database material may be text, computer programs, graphics, audio, spreadsheets, or any other material which may be stored and indexed. Database material may be in one or multiple sources, and annotations may be stored together with the original material or in a separate store. Annotations can be used to capture information such as additional facts about the database material, the opinions and judgments of experts about the database material, and/or links to other related material. Annotations may be captured in a structured form to enhance queryability and semantic interpretation.

System for annotating a data object by creating an interface based on a selected annotation structure

A similarity search method includes generating a feature database which stores data pertaining to a candidate molecule, as executed by a processor of a computer, the database including a hash table having entries which are generated based on, a set of descriptors generated from conformations of fragment graphs of the candidate molecule, the fragment graphs including plural fragment nodes connected by rotatable bond edges, a specific conformation of the fragment node including a fragment of the candidate molecule, and two neighboring fragments connected by a rotatable bond at a specific dihedral angle including a fragment pair, and a context-adapted descriptor-to-key mapping which maps the set of descriptors to a set of feature keys including indices that label grid cells in discriminant space.

A field-based similarity search system and method includes a database for storing at least one candidate molecule, an input device for inputting a query molecule, and a processor for identifying a candidate molecule which is similar to the query molecule based on a similarity of fragment pair features.

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Morgan Hill, CA, United States of America

William Clarence Swope