General Electric Company

Global Life Sciences Solutions Operations UK Ltd

William Christopher Alberts

Arunkumar Natarajan

Vadim Bromberg

Kwok Pong Chan

David Roger Moore

Bing Li

John Richard Nelson

Joshua Tyler Mook

Xi Yang

Mary Kathryn Thompson

Ananda Barua

Brian Christopher Bales

Frank John Mondello

Travis Gene Sands

Cathryn Ellen Olsen

Jacob Mayer

Jason Michael Nichols

William Cosmo Murphy

Omayra Liz Padilla De Jesus

Robert Edgar Estes

Janet Mekker

In various embodiments, a water-based binder solution for use in additive manufacturing, includes a thermoplastic binder. The thermoplastic binder includes a first polymer strand having a weight average molecular weight (Mw) of from greater than or equal to 5,000 g/mol to less than or equal to 15,000 g/mol, a second polymer strand having a weight average molecular weight of from greater than or equal to 10,000 g/mol to less than or equal to 50,000 g/mol, and a third polymer strand having a weight average molecular weight of from greater than or equal to 1,000 g/mol to less than or equal to 5,000 g/mol. The binder solution further comprises from greater than or equal to 0.1 wt % to less than or equal to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100° C.

Water-based binder solutions for use in additive manufacturing processes

A water-based binder solution comprises a thermoplastic binder, greater than or equal to 4 wt % to less than or equal to 20 wt % of a non-aqueous solvent having a boiling point greater than or equal to 100° C. and less than or equal to 175° C., and water. The thermoplastic binder comprises a first polymer strand having a weight average molecular weight (Mw) of from 5,000 g/mol to 15,000 g/mol; and at least one of a second polymer strand having a weight average molecular weight (Mw) of from 10,000 g/mol to 50,000 g/mol and a third polymer strand having a weight average molecular weight (Mw) of from 1,000 g/mol to 5,000 g/mol. A method of monitoring a print head of an additive manufacture process comprises depositing a water-based binder solution on the thermal paper.

Embodiments of the present disclosure are directed to additive manufacturing apparatuses, cleaning stations incorporated therein, and methods of cleaning using the cleaning stations.

Cleaning fluids for use in additive manufacturing apparatuses and methods for monitoring status and performance of the same

Various embodiments provide a method of additively manufacturing a part including depositing a layer of a powder on a working surface, depositing a binder solution on the layer of the powder at first locations, and depositing a sintering aid solution on the layer of the powder at second locations. The sintering aid solution comprises a sintering aid in a solvent. In various embodiments, the sintering aid enables an increased brown strength as compared to parts containing unbound powder. The method enables binders that provide high green strength to be used at the edges of the part, while also balancing a shortened debind time with an increased brown strength. Embodiments in which binder solution is deposited according to a predetermined pattern at second locations are also described.

Method of edge printing for use in additive manufacturing processes

A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).

Porous membranes with a polymer grafting, methods and uses thereof

A method of manufacturing a green body part comprises depositing a layer of a powder on a working surface; and selectively depositing a binder solution comprising a thermoplastic binder, a fluorescent material, and a binder medium into the layer of powder in a pattern representative of a structure of a layer of the green body part. The thermoplastic binder comprises one or more polymer strands dissolved in a solvent medium having an average molecular weight from greater than or equal to 7,000 g/mol to less than or equal to 100,000 g/mol. Binder solutions comprising fluorescent material and green body parts adhered together using the same are also disclosed.

Fluorescent binders for use in monitoring additive manufacturing processes

A method of manufacturing comprises depositing a layer of a powder on a working surface and selectively depositing a water-based binder solution comprising from 0.1 wt % to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100&#xb0; C. and less than or equal to 175&#xb0; C. at 1 atm and a thermoplastic binder comprises a first polymer strand including a first functional group and a second polymer strand including a second functional group into the layer of powder in a pattern representative of a structure of a part. The method further comprises non-covalently coupling the first and second polymer strands together via interaction between the first and second functional groups to form a green body part.

Water-based binders and methods of use in additive manufacture of parts

In various embodiments, a water-based binder solution for use in additive manufacturing, includes a thermoplastic binder. The thermoplastic binder includes a first polymer strand having a weight average molecular weight (Mw) of from greater than or equal to 5,000 g/mol to less than or equal to 15,000 g/mol, a second polymer strand having a weight average molecular weight of from greater than or equal to 10,000 g/mol to less than or equal to 50,000 g/mol, and a third polymer strand having a weight average molecular weight of from greater than or equal to 1,000 g/mol to less than or equal to 5,000 g/mol. The binder solution further comprises from greater than or equal to 0.1 wt % to less than or equal to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100&#xb0; C.

An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

Electrospun fibers for protein stabilization and storage

The invention provides a method and article for storing genetic material or analytes from a biological sample by contacting said biological sample with a cellulose substrate comprising structural units of Formula I wherein X and Y are independently N&#x2014;O-L-A or O, with the proviso that when Y is O, then X is N&#x2014;O-L-A, and when X is O, then Y is N&#x2014;O-L-A; L is a direct bond, an aliphatic radical, an aromatic radical, a cycloaliphatic radical, or a combination thereof; and A=COOH, SO3H, or a combination thereof. The invention also relates to a cellulose substrate comprising the structural units of Formula I, and a method of manufacturing the same.

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Saratoga Springs, NY, United States of America

William Christopher Alberts