Migenix, Inc.

Mitokor, Inc.

Knuedge, Inc.

William Christensen Clevenger

Robert E Davis

Sandra Eileen Wiley

Soumitra S Ghosh

Christen M Anderson

Walter H Moos

Yazhong Pei

Tomas R Szabo

Scott W Miller

Corinna Herrnstadt

Eoin D Fahy

Anne N Murphy

Alexander Y Andreyev

Luciano G Frigeri

Douglas A Palmer

Gonul Velicelebi

Jerome Vincent Coffin

Gonul Velecelebi

A computing system includes a plurality of computing resources that communicate with each other using network on a chip architecture. One of the plurality of computing resources is attached to memory external to the computing system through an external memory interface. The memory-attached computing resource is configured to read data from the memory and modify the read data prior to either writing the modified data back to the memory, or transmitting the modified data to one or more other of the computing resources, or both.

Memory-attached computing resource in network on a chip architecture to perform calculations on data stored on memory external to the chip

Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor.

Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.

Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions

Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions

Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.

Diagnostic method based on quantification of extramitochondrial DNA

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San Diego, CA, United States of America

William Christensen Clevenger