Monsanto Technology LLC

Monsanto Company

Pharmacia Corporation

William Carlton Stallings

Ganesh M Kishore

Gerard Francis Barry

Stephen Rogers Padgette

Stanislaw Flasinski

Paul C C Feng

Gregory R Heck

Murtaza F Alibhai

Youlin Qi

Claire Cajacob

Gary A DeCrescenzo

Joseph J McDonald

Susan C Howard

Huey S Shieh

Paul C Feng

The compositions and methods disclosed herein provide novel DNA molecules that encode glyphosate resistant EPSPS proteins and plants containing these new proteins. The plants that express the new EPSPS proteins are themselves tolerant to the herbicidal effects of glyphosate.

Glyphosate resistant class I 5-endolpyruvylshikimate-3-phosphate synthase (EPSPS)

Glyphosate resistant class I 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)

Genes encoding Class II EPSPS enzymes are disclosed. The genes are useful in producing transformed bacteria and plants which are tolerant to glyphosate herbicide. Class II EPSPS genes share little homology with known, Class I EPSPS genes, and do not hybridize to probes from Class I EPSPS's. The Class II EPSPS enzymes are characterized by being more kinetically efficient than Class I EPSPS's in the presence of glyphosate. Plants transformed with Class II EPSPS genes are also disclosed as well as a method for selectively controlling weeds in a planted transgenic crop field.

Antibody immunoreactive with a 5-enolpyruvylshikimate-3-phosphate synthase

Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases

The present invention provides a matrix metalloproteinase inhibiting compound having structure (VIII) or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformation of a matrix metalloproteinase, a method of inhibiting a matrix metal metalloproteinase, and a method of treating osteoarthritis.

Method of changing conformation of a matrix metalloproteinase

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Glencoe, MO, United States of America

William Carlton Stallings