Astra Aktiebolag

William Calvin Shakespeare

James Edwin MacDonald

James Russell Matz

Robert John Murray

Robert James Gentile

James Macdonald

Compounds

There are provided novel compounds of formula (I) ##STR1## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy.

Amidine and isothiourea derivatives as inhibitors of nitric oxide

There are provided compounds of formula (I), ##STR1## wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro or cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents N(X) or CH(--(CH.sub.2).sub.m --NXY); U represents NH, O or CH.sub.2 ; V represents (CH.sub.2).sub.a ; W represents (CH.sub.2).sub.b ; a, b, m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy.

Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase

The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include stroke, schizophrenia, anxiety, and pain.

Amidine derivatives with nitric oxide synthetase activities

Amidine and isothiourea derivatives, compositions containing them and

Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase

Growing community of inventors

Rochester, NY, United States of America

William Calvin Shakespeare