Wisconsin Alumni Research Foundation

William C Pomerantz

Samuel Helmer Gellman

Nicholas Lawrence Abbott

Sean Paul Palecek

Li Guo

William Seth Horne

Yonggui Chi

Emily P English

Amy J Karlsson

The present invention is directed to the design, synthesis and use of various &#x3b2;-peptides exhibiting antifungal activity. The &#x3b2;-peptides are relatively short in length, adopt globally amphiphilic conformations, and cause little lysis of human red blood cells at concentrations that kill, a common human fungal pathogen.

Beta-peptides with antifungal activity

The present invention provides materials and methods that make liquid crystal phases accessible with relatively short &#x3b2;-peptides in aqueous solvents.

&#x3b2;-peptide lyotropic liquid crystals and methods of manufacture and use thereof

The present invention provides a method for the synthesis of &#x3b2;-amino acids. The method also provides methods yielding &#x3b1;-substituted &#x3b2;-amino aldehydes and &#x3b2;-substituted &#x3b3;-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of &#x3b2;-amino acids.

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Growing community of inventors

Madison, WI, United States of America

William C Pomerantz