Prognomiq, Inc.

University of California

Chiron Corporation

William C Manning, Jr

Omid C Farokhzad

John E Blume

Gregory Troiano

Philip Ma

Asim Siddiqui

Varavani J Dwarki

Katherine Rendahl

Fei Wang

Shangzhen Zhou

Sheldon S Miller

Disclosed herein are methods and compositions for processing biofluid samples. Some such methods may include obtaining a biofluid sample from a subject having a disease state such as lung cancer. The biofluid sample may be contacted with a nanoparticles to adsorb proteins. The proteins may then be ionized or contacted with a detection reagent. Also disclosed herein are compositions comprising proteins coupled to a nanoparticle upon contact of the nanoparticle with a biofluid sample from a subject having a disease.

Methods of processing a biofluid sample

Disclosed herein are biomarkers associated with a disease state such as lung cancer, and methods of discovering or using biomarkers. Also disclosed herein are classifiers built on biomarkers and methods of detecting the disease state in samples from subjects. The method may include obtaining a data set that includes protein information from a biofluid sample, and may involve using a classifier to identify the sample as indicative of a healthy state, a disease state, or a comorbidity.

Lung biomarkers and methods of use thereof

Gene delivery vectors, such as, for example, recombinant adeno-associated viral vectors, and methods of using such vectors are provided for use in treating or preventing diseases of the eye.

Use of recombinant gene delivery vectors for treating or preventing diseases of the eye

Growing community of inventors

Redwood City, CA, United States of America

William C Manning, Jr