Biomagnetic Technologies, Inc.

William C Black, Jr

Douglas N Paulson

Eugene C Hirschkoff

Mark S DiIorio

Stephen E Robinson

David S Buchanan

John P Wikswo

Waldo Stephen Hinshaw

D Scott Buchanan

James R Marsden

Richard T Johnson

Stephen O James

A magnetometer includes a support. The support has two support surfaces that intersect each other along an intersection line. The intersection line is perpendicular to a reference axis of the support. The support surfaces are preferably perpendicular to each other and are each inclined at an angle of 45 degrees to the reference axis. A planar sensor/detector array is mounted on each support surface. Each array includes at least two pairs of magnetic field sensors and associated SQUID detectors arranged such that the magnetic field sensors lie on a line that is parallel to the intersection line of the two support surfaces. The magnetometer can be used adjacent to a surface to measure components and spatial variation of the magnetic field near the surface, with the measured components resolved into the magnetic field vectors parallel to and perpendicular to the surface.

Magnetometer and method of measuring a magnetic field

A biomagnetometer includes a magnetic field sensor unit having a magnetic field pickup coil. A vessel contains the sensor unit. The vessel includes a flexible contact face with the magnetic field sensor unit mounted in the interior of the vessel adjacent to the flexible contact face. Insulation at the flexible contact face of the vessel prevents excessive heat flow through the flexible contact face. Pickup units using this structure can be connected together into flexible or rigid arrays. In operation, the pickup coil is cooled to a temperature of less than its superconducting transition temperature. A detector measures the magnitude of magnetic fields sensed by the sensor unit.

Biomagnetometer having flexible sensor

Signals produced by brain activity are measured by each sensor of an array of magnetic and/or electrical sensors external to but proximate to the head (or other portion of the body) of a subject. The measurements obtained simultaneously from all of the sensors are combined in a manner to permit selective measurement of the electrical activity from a specified location within the body, or alternatively, to permit the location in the body producing a particular type of response to be identified. The instantaneous measurement of each sensor is scaled by a weighting coefficient for that sensor, and the products added over all of the sensors. The weighting coefficients are calculated from the covariance matrix of the measurements made by the array of sensors.

Analysis of biological signals using data from arrays of sensors

A biomagnetometer has a magnetic pickup coil positioned remotely from a detector and inductively coupled to the detector. The detector is preferably made from a low-temperature superconductor, while the pickup coil can be made of a high-temperature superconductor. The detector and pickup coil can therefore be placed into separate containers, with an inductive coupler between the containers. In one approach, the detector is maintained at liquid helium temperature, and the pickup coil and electrical connector are cooled by liquid nitrogen. The resulting biomagnetometer permits the container with the pickup coil to be moved and positioned easily, and to be changed readily between various configurations particularly suited for performing various functions.

Superconducting biomagnetometer with inductively coupled pickup coil

A biomagnetometer has a magnetic pickup coil positioned remotely from the detector. The detector is made from a low-temperature superconductor, while the pickup coil and an electrical connector between the detector and the pickup coil are made of a high-temperature superconductor. Although the detector is maintained in a dewar at a sufficiently low temperature to reduce electronic noise, the pickup coil and the electrical connector need only be maintained at a temperature at which they are superconducting. In one approach, the detector is maintained at liquid helium temperature, and the pickup coil and electrical connector are cooled by liquid nitrogen. The resulting biomagnetometer permits the pickup coil to be moved and positioned easily, and to be changed readily.

Superconducting biomagnetometer with remote pickup coil

Signals produced by brain activity are measured by each sensor of an array of magnetic and/or electrical sensors external to but proximate to the head (or other portion of the body) of a subject. The measurements obtained simultaneously from all of the sensors are combined in a manner to permit selective measurement of the electrical activity from a specified location within the body, or alternatively, to permit the location in the body producing a particular type of response to be identified. The instantaneous measurement of each sensor is scaled by a weighting coefficient for that sensor, and the products added over all of the sensors. The weighting coefficients are calculated from a mathematical model of the brain that includes information on the shape of the potential source, the extent or type of source activity, the electrical and magnetic properties of the media, and the locations and orientations of the sources and the sensors.

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Del Mar, CA, United States of America

William C Black, Jr