The Australian National University

Pharmaxis Pty Limited

William Butler Cowden

Christopher Richard Parish

David Otto Willenborg

Darren Ray March

Gavin James Bartell

Bart Michael Eschler

Douglas John Francis

Alan Duncan Robertson

Sendaba Gerba

Brett Charlton

Lawrence Scott Gazda

Kevin John Lafferty

Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.

Mannose-6-phosphonate compounds for the treatment of inflammatory diseases

The present invention provides phosphotetrahydropyran compounds and the use thereof in treating diseases or conditions that are dependent on T-lymphocyte migration, as well as compositions containing said compounds.

Compounds and methods

Therapeutic compositions including a species of Coxiella or one or more antigenic components therefrom or analogous or homologous components thereof are disclosed. These compositions are useful in preventing, inhibiting, delaying onset of or otherwise ameliorating the effects of an autoimmune disease in a mammal, particularly insulin-dependent diabetes mellitus (IDDM). They arm also useful in prolonging survival of islet tissue transplanted into a mammal.

Use of coxiella bacteria to treat autoimmune disease

The present invention relates generally to sulfated oligosaccharides, and in particular to the use of certain sulfated oligosaccharides as agents for lowering blood levels of triglycerides such as, for example in treatment of hypertriglyceridaemia.

Use of sulfated oligosaccharides in lowering blood triglyceride levels

Use of sulfated oligosaccharides as inhibitors of cardiovascular disease

-mannoside-6-phosphate compounds having anti-inflammatory activity are disclosed, and use thereof in treating inflammatory diseases, particularly cell-mediated inflammatory diseases.

Phosphosugars and phosphosugar-containing compounds having anti-inflammatory activity

Sulfated oligosaccharides having anticoagulant/antithrombotic activity

Preparation and use of sulfated oligosaccharides

A method of anti-inflammatory and/or immunosuppressive treatment of a human or otheer warm-blooded animal patient comprises administration to the patient of an effective amount of castanospermine.

Use of castanospermine as an anti-inflammatory and immunosupressant agent

Castanospermine as an anti-inflammatory and immunosuppressant agent

The invention relates to a method of anti-inflammatory and/or immunosuppressive treatment of an animal or human patient comprising administering to the patient an effective amount of at least one phosphosugar or derivative thereof, or a phosphosugar-containing oligosaccharide or polysaccharide or derivative thereof.

Growing community of inventors

Kambah, Australia

William Butler Cowden