National Technology & Engineering Solutions of Sandia, LLC

Arizona State University

William Arndt

Thayne L Edwards

Bryan Carson

Jason C Harper

Melissa Finley

Bertram L Jacobs

Jeffrey O Langland

Karen Kibler

Kelly Trainor

Chandra Mitnik

Heather Koehler

Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.

Oncolytic vaccinia virus mutants and using same for cancer treatment

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Amplification of biological targets via on-chip culture for biosensing

Growing community of inventors

Albuquerque, NM, United States of America

William Arndt