Nycomed Imaging As

Amersham Health As

William Anthony Sanderson

Robert A Snow

Paul Mark Henrichs

Eric Paul Hohenschuh

Edward R Bacon

Daniel J Delecki

Vinay Chandrakant Desai

Kenneth Robert Hollister

Jan Alan Alfheim

Edvin Wilheim Johannesen

A method of treatment of a human or animal body by sonodynamic therapy in which a sensitizer agent is administered to the body and the body is exposed to ultrasound to achieve a cytopathogenic effect at a site therein, wherein the said sensitizer agent is a physiologically tolerable substance which is capable of enhancing the cytopathogenic efficacy of said sonodynamic therapy. Preferably, the sensitizer agent is a water-soluble polymer compound or a conjugate thereof.

Sonodynamic therapy using an ultrasound sensitizer compound

This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 5000000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkylene oxide (PAO) moiety having a molecular weight in the range 60 to 100000.

Compounds

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Wayne, PA, United States of America

William Anthony Sanderson