Covidien LP

Rf Surgical Systems, Inc.

View Point Medical, Inc.

Tmrw Life Sciences, Inc.

Skypipes Wireless, Inc.

William Alan Blair

David A Poirier

Bruce E Barnes

Curtis Crump

John Merritt

Mike Jones

Timothy Alan Sharp

John T Buhler

William Nicholas Garbarini, Jr

Amit Gupta

Kathryn Josephine Go

Tom Kane

Michael Golden

Kathryn Jospehine Go

William Nicholas Garbarini

John Buhler

Markers for use in bodily tissue take a variety of forms, and may include a plurality of ultrasound reflective elements, for example hollow shells filled with air, and a hydrogel that binds the ultrasound reflective elements. The hydrogel may be natural or artificial and may be cross-linked. An ultrasound system advantageously injects variance in a drive signal, that varies a frequency or phase of an ultrasound interrogation signal from a nominal frequency or nominal phase. The amount of variation is preferable one to six orders of magnitude less than the nominal frequency or phase. The ultrasound system can present or detect a twinkling artifact at least in a Doppler mode of operation, resulting from interaction of the varying interrogation signal with the ultrasound reflective elements.

Ultrasound marker detection, markers and associated systems, methods and articles

Various embodiments of wirelessly detectable objects to be used in medical procedures are provided. Such may employ ionizing radiation hard wireless radio frequency identification (RFID) transponders, other wireless transponders and/or integrated circuits, and attachment structures, all of which retain structural and functional integrity when exposed to standard sterilization dosages of ionizing radiation. Additionally or alternatively, the wireless radio frequency identification (RFID) transponders, other wireless transponders and/or integrated circuits, and attachment structures, may retain structural and functional integrity when exposed to standard sterilization temperatures and/or pressures.

Sterilizable wirelessly detectable objects for use in medical procedures and methods of making same

A system and method facilitates transfers of specimen containers (e.g., vials with caps) between storage cassettes and carrier cassettes. The storage cassettes are designed to be stored in cryogenic refrigerators while the carrier cassettes are designed to be temporarily stored in a portable carrier. Identification information is read from wireless transponders carried by the specimen containers. Visual mappings of the positions of the specimen container in the cassettes is provided. Presence and position of the specimen containers in the cassettes is verified, and alerts of inconsistencies provided along with corrective commands. Inventories of specimen container and even specific specimen holders are provided.

Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions

Imaging marker embodiments that may be used for marking sites within a patient's body are discussed. Some imaging marker embodiments are particularly useful for imaging with ultrasound imaging modalities and some imaging marker embodiments may be suitable for imaging with multiple modes of imaging modalities. Method embodiments for making and using imaging markers are also discussed herein.

Multi-mode imaging markers

Aspects of the invention relate to composite markers that employ a gel carrier to carry two or more contrast materials, each detectable by a detection modality different than one another. Kits and methods for forming these composite markers and methods of marking a target site in a mammalian subject employing these composite markers are also discussed herein.

Composite tissue markers detectable via multiple detection modalities

Composite markers employ a gel carrier to carry at least one radiopaque element (e.g., wire or band or clip) and one or more other contrast materials, each detectable by a detection modality different than one another. Methods for forming these composite markers and methods of marking a target site in a mammalian subject employing these composite markers are also discussed herein.

Composite tissue markers detectable via multiple detection modalities including radiopaque element

A container includes a vial, cap, and one or more wireless transponders secured to the cap, the vial or a jacket to store and identify samples of biological material at cryogenic temperatures (e.g., vitrified biological samples), for instance held by cryopreservation storage devices. A specimen holder may be extend from the cap. The vial and/or cap includes ports or vents. A carrier includes a box, thermal shunt, thermal insulation to store and identify arrays of containers that hold cryopreservation storage devices with samples of biological material at cryogenic temperatures. Various apparatus include wireless transponders positioned and oriented to enhance range, and allow interrogation while retained in a carrier. Various apparatus can maintain the biological material at or close to cryogenic temperatures for prolonged period of times after being removed from a cryogenic cooler, and can allow wireless inventorying while maintaining the biological samples at suitably cold temperatures.

Apparatus to preserve and identify biological samples at cryogenic conditions

A hand-held antenna system allows medical personnel to ascertain the presence or absence of objects (e.g., medical supplies) tagged with transponders in an environment in which medical procedures are performed. In use, the hand-held antenna system may be positioned proximate a patient at a time after a medical procedure, such as after child birth, so the system can scan the patient's body to determine the presence of objects tagged with transponders. The antenna system includes three antenna elements arranged mutually orthogonal to each other to transmit and receive signals in three coordinate directions. A controller is coupled to the antenna elements to transmit signals to the transponders and to receive response signals. The antenna system may operate in a static scan mode wherein the antenna system is held in a fixed position by a user and a dynamic scan mode wherein the antenna system is moved by a user.

Hand-held spherical antenna system to detect transponder tagged objects, for example during surgery

Apparatuses and methods to physically couple a transponder to a surgical object are provided. One example apparatus includes a first clamp comprising a first fastener and a first channel member that has a first base and a first pair of side portions that extend from the first base to form a first channel therebetween. The first fastener adjustably engages with the first channel member to securingly clamp a surgical object in the first channel of the first channel member. The apparatus further includes a housing that has at least a first cavity that receives at least a portion of the first pair of side portions of the first channel member, a first passageway that receives the first fastener and permits the first fastener to extend at least in part into the first cavity, and a second passageway to receive at least one transponder that wirelessly receives and returns signals.

Growing community of inventors

San Diego, CA, United States of America

William Alan Blair