Koninklijke Philips Corporation N.V.

William A Truschel

Anandi Mahadevan

Mark Christopher McDermott

Christopher Anthony Procyk

Ronald Cyprowski

Mark Christopher Mcdermott

Ljubisa Milojevic

Nathan John Berry Ann

A pressurized flow of breathable gas is delivered to the airway of a subject in accordance with a therapy regimen. The therapy regimen calls for maintenance of an average tidal volume. The therapy ensures that the subject breaths at a therapeutic breath rate. The breath rate may be determined dynamically based on breathing of the subject early on in a therapy session and/or based on a detected wakefulness of the subject. Inspiration for spontaneous and non-spontaneous breaths may be supported at different levels. The therapy regimen further maintains a beneficial positive end expiratory pressure, to reduce respiratory obstructions and/or for other purposes.

Obesity hypventilation syndrome treatment system and method

A pressurized flow of breathable gas is delivered to the airway of a subject in accordance with a therapy regimen. One or more fluid parameters of the pressurized flow of breathable gas are adjusted based on the therapy regimen. The therapy regimen dictates that such adjustments be made based on the respiratory state of the subject. Transitions in respiratory state are identified without relying on measurement or estimation of flow at or near the airway of subject. Transitions in respiratory state are identified based on changes in the first time derivative of flow at or near the airway of the subject. In one embodiment, an effort parameter is determined that approximates the second time derivative of flow. Based on comparisons of the effort parameter to a dynamic threshold, transitions in respiratory state are identified.

System and method for identifying breathing transitions

The disclosed concept maintains that Q=Q&#x2212;Q, where, Qis the estimated patient flow, Qis the estimated leak and Qis the measured total circuit flow. Qis given by a transfer function &#x3c6;(&#x3c7;) where x is a set of independent measured or fixed variables. The transfer function is thus Q=&#x3c6;(&#x3c7;). The transfer function (&#x3c6;(&#x3c7;) is adjusted given the constraint that, Qshall be zero. The transfer function converges over time to accurately estimate the leak because over an extended time the mean patient flow will always be zero. In one example, &#x3c6;(&#x3c7;)=gPand the coefficient gis adapted until Qis zero.

Leak estimation using function estimation

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Eindhoven, Netherlands

William A Truschel