Cepheid Corporation

Profusa, Inc.

Other

Syntex (u.s.a.) Inc.

William A McMillan

Ronald G Chang

Farzad Pourahmadi

Kurt Edward Petersen

M Allen Northrup

Lee Allan Christel

Jesus Ching

Gregory T A Kovacs

Douglas Bryan Dority

Natalie Wisniewski

Steven Jay Young

Michael T Taylor

Stanley H Sakai

Phillip Belgrader

Kristen Helton

Gregory J Kintz

Soya Gamsey

David A Borkholder

Robert Allan Yuan

Raymond T Hebert

Konstantin Othmer

Gregory T Kovacs

Philip Belgrader

Ken DeGrave

Christel A Lee

Brad Rice

Gregory Ta Kovacs

Northrup M Allen

Petersen E Kurt

Douglas P Dority

Kurt E Peterson

Frazad Pourahmadi

Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.

Apparatus and methods for detecting optical signals from implanted sensors

Some embodiments described herein relate to a sensor that includes an analyte-sensing dye and a reference dye. The analyte-sensing dye can be configured to emit an analyte-dependent optical signal in the presence of an analyte. Similarly stated, the intensity and/or duration of the analyte-dependent optical signal can be modulated by a quantity and/or concentration of the analyte in the environment of the sensor. The reference dye can be configured to emit an analyte-independent optical signal. The analyte-dependent optical signal and the analyte-independent optical signal have an analyte-dependent spectrum and an analyte-independent spectrum, respectfully. The analyte-dependent optical spectrum and the analyte-independent spectrum can be the same, substantially the same, and/or overlapping. The analyte-dependent optical signal can have a duration of lifetime that is shorter than a duration or lifetime of the analyte-independent optical signal.

System and single-channel biosensor for and method of determining analyte value

An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

Method and device for correcting optical signals

Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Oxygen sensors

The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.

Method and system for directing a localized biological response to an implant

Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Tissue-integrating sensors

Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.

Tissue-integrating electronic apparatus

An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.

Apparatus and method for cell disruption

The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.

Device for extracting nucleic acid from a sample

Growing community of inventors

Cupertino, CA, United States of America

William A McMillan