Southwest Research Institute

Other

Med USA

Alistagen Corporation

Baker Hughes Corporation

Gas Research Institute

Pullman Incorporated

Fiberglas Canada Inc.

The United States of America As Represented by the Administrator of

Enviroguard

Materials Evolution and Development Usa, Inc.

Glynson Industries, Inc.

Dynastone Lc

Earth Protection Systems, Inc.

William A Mallow

Mark B Lyles

Glenn A Halff

Charles A McLaughlin

Jerome J Dziuk, Jr

Steven R Radford

Larry B Rogers

Pierre E Collee

Jesse R Conner

Bryan Glynson

Dorothy P Enright

Roy S Rieber

Howard S Silvus, Jr

Robert D Young

Charles H Parr

Clifford A Moses

Robert P Wood

Henry L Bernstein

Roy S Reiber

Fred O Hoese

C William Hall

Gabriel M Gelb

Scott Stropkay

Charles A Mclaughlin

An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks passage of pathogenic microorganisms along percutaneously implanted objects. In embodiments for drug delivery, a reservoir of the same biomaterial may contain either (1) a cell culture system enclosed within a porous sealable interior chamber or (2) a biodegradable matrix in which one or more drugs are dispersed. After implantation of a reservoir of the first embodiment in an organism, cultured cells obtain food and oxygen via diffusion in tissue fluid through the porous walls of the interior chamber, while metabolic products, including drugs, diffuse away from the cell culture in an analogous manner. In a reservoir of the second embodiment, a biodegradable matrix substantially fills the pores (voids), and progressive dissolution of the matrix releases one or more drugs into surrounding tissue fluid. Reservoirs of either embodiment comprise a plurality of voids of a predetermined size effective for stimulating angiogenesis from the surrounding vascular tissue into at least a portion of the reservoir. The reservoir thus acts to couple a source: of drugs to the circulatory system of the organism.

Implantable system for cell growth control

A biocidal film-forming composition, preferably a paint, is disclosed, comprising hydrated lime, alkaline potassium salt, and a non-ionic polyolefinic latex resistant to hydrated-lime induced coagulation and phase separation. Also disclosed is the method of making certain such composition wherein hydrated lime is admixed with a non-ionic polyolefinic ester latex with agitation and continuing such agitation until hydrolysis of the ester is substantially completed and rheology of the composition is stabilized and the incidence of gelation is eliminated.

Stabilized biocidal coating composition and method

An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks passage of pathogenic microorganisms along percutaneously implanted objects. In embodiments for drug delivery, a reservoir of the same biomaterial may contain either (1) a cell culture system enclosed within a porous sealable interior chamber or (2) a biodegradable matrix in which one or more drugs are dispersed. After implantation of a reservoir of the first embodiment in an organism, cultured cells obtain food and oxygen via diffusion in tissue fluid through the porous walls of the interior chamber, while metabolic products, including drugs, diffuse away from the cell culture in an analogous manner. In a reservoir of the second embodiment, a biodegradable matrix substantially fills the pores (voids), and progressive dissolution of the matrix releases one or more drugs into surrounding tissue fluid. Reservoirs of either embodiment comprise a plurality of voids of a predetermined size effective for stimulating angiogenesis from the surrounding vascular tissue into at least a portion of the reservoir. The reservoir thus acts to couple a source of drugs to the circulatory system of the organism.

Porous drug delivery system

An apparatus and method for visually and continuously monitoring gaseous concentrations of electrophiles such as carbon dioxide. A coating composition comprising an organic binder, filler/pigment, an activator, and carbon dioxide sensitive color indicator interacts with a primed substrate to which it is applied for support. The coated primed substrate may then be used for estimation of carbon dioxide concentration by the detection of a substantially instantaneous and reversible color change of the coated primed substrate.

Reversible detector for gaseous carbon dioxide

Disclosed is a commercial grade of soluble silicate solutions, clear homogenous and water white essentially free of unreacted silica, made by dissolving in a closed container biogenic silica, preferably rice hull ash, in a strong alkali solution, preferably sodium hydroxide in the presence of an agent, such as an active carbonaceous material, which prevents discoloration of the soluble silicates by absorbing and/or reacting with polyvalent metals, organic materials, and the like, in the biogenic silica as it dissolves in and reacts with the alkali solution. The invention takes advantage of the residue of such active carbonaceous material on the biogenic silica, such as rice hulls, left by commercial energy burning thereof which effectively prevents discoloration. A solid residue results from the method which is an active carbonaceous material including concentrated manganese from the biogenic silica, both of which are valuable commercial products.

Production of soluble silicates from biogenic silica

A thermal barrier protective coating composition having a thickness sufficient to protect a metal surface against heat, vibration, corrosive, and environmental damage and a method for making the same. The coating composition comprises polymerizable spray-dried hydrated sodium silicate powder, a forming agent, and lightweight ceramic microspheres is disclosed.

Protective coating and method

System for cell growth

A method for protecting integrity of a core sample during transport from a subterranean formation to the surface comprising: cutting a core sample from the subterranean formation using a drilling fluid; encapsulating the core sample with an encapsulating material that is separate from the drilling fluid and comprises a property which renders the encapsulating material capable of protecting the chemical integrity of the core sample during transport from the subterranean formation to the surface, wherein the property is other than a property selected from the group consisting of a viscosity which increases in response to a decrease in temperature and an ability to solidify in response to a decrease in temperature; and, transporting the encapsulated core sample from the subterranean formation to the surface.

Method for preserving core sample integrity

A biocidal film-forming composition, preferably a paint, is disclosed, comprising hydrated lime and a non-ionic polyolefinic latex resistant to hydrated-lime induced coagulation and phase separation. Also disclosed is the method of making certain such composition wherein hydrated lime is admixed with a non-ionic polyolefinic ester latex with agitation and continuing such agitation until hydrolysis of the ester is substantially completed and rheology of the composition is stabilized.

Biocidal coating compositions and method

The present invention prolongs the biocidal activity of hydrated lime in a paint or coating by using a sufficient amount of a binder in the paint or coating to block carbon dioxide from reacting with the hydrated lime while still producing a coating that is durable and adhesive upon drying and not unduly friable due to the amount of hydrated lime in said coating.

Biocidal coating composition

The present invention prolongs the biocidal activity of hydrated lime in a paint or coating by using a sufficient amount of a binder in the paint or coating to block carbon dioxide from reacting with the hydrated lime while still producing a coating that is durable and adhesive upon drying and not unduly friable due to the amount of hydrated lime in said coating

A method of fixation of hazardous waste materials is disclosed wherein the hazardous waste is admixed with materials capable of reacting in situ to form zeolites and the mixture subjected to conditions sufficient to form zeolites in which the hazardous material is part of the zeolite structure. The invention also relates to the resultant synthetic zeolite and to products formed by embedding the synthetic zeolites in a modified sulfur cement.

Fixation of hazardous wastes and related products

A method is disclosed for making dibasic amino acid monoesters useful in repair of teeth in which a dibasic amino acid is partially esterified with an allylic acrylic compound in the presence of an acidic ion-exchange resin at ambient temperature. The invention also comprises cyclicizing the amino groups of the monoesters.

Method of making amino acid acrylic monoesters

Growing community of inventors

Helotes, TX, United States of America

William A Mallow