Gilead Sciences, Inc.

Syntex (u.s.a.) Inc.

Magic Leap, Inc.

California Biotechnology Inc.

William A Lee

Peter H Nelson

Anthony C Allison

Elsie M Eugui

Chee-Liang L Gu

Choung U Kim

William John Watkins

Xiaowu Chen

Richard L Mackman

Hyung-Jung Pyun

Adrian S Ray

James Ming Chen

Lee Shun Chong

Maria Fardis

Haolun Jin

Ernest J Prisbe

Christopher P Lee

Aesop Cho

Jennifer R Zhang

Thorsten A Kirschberg

David A Oare

Sundaramoorthi Swaminathan

Carina E Cannizzaro

Constantine G Boojamra

Alan X Huang

David Y Markevitch

Gong-Xin He

Vidya K Prasad

Ralph F Hirschmann

Brian T Schowengerdt

Charles David Melville

Mathew David Watson

Kuei-Ying Lin

John C Rohloff

Robert J Jones

Norbert W Bischofberger

Murty N Arimilli

Manoj C Desai

Zheng-Yu Yang

Jianying Wang

Michael S Louie

Rosemarie Sherlock

Mark L Sparacino

Shigeru G Natsume

John Francis Shanley, Iv

Lawrence R McGee

Lianhong Xu

Edward Doerffler

Lijun Zhang

Tomas Cihlar

Gary Paul Cook

Kenneth C Cundy

Eugene J Eisenberg

Xiaoqin Cheng

Rosemarie O'Shea

Mark W Becker

Harlan H Chapman

Michael R Kernan

Masumune Kaji

Matthew A Williams

Philip L Felgner

Michael L Mitchell

Hongtao Liu

Steven Cesar Alfons De Jonghe

Piet André Maurits Maria Herdewijn

Steven H Krawczyk

Richard Yu

Noelene E Byars

Deborah M Lidgate

John P Longenecker

Craig S Gibbs

Cherng-chyi Fu

Daniel B Tumas

Jiancun Zhang

Sundaramoorthi Swaninathan

Linda C Foster

Murty N Arimili

Richard Ennis

Yu-chang J Wang

Blair Narog

Hans Reiser

James D Tario

Patricia A Baldwin

Lawwrence R Mcgee

Xiaqin Cheng

Gary P Cook

Richard H Yu

Mark Sparacino

Tanisha D Rowe

Azar Dastgah

Mark M Becker

An improved headset is provided to selectively distribute the weight of the headset while securely registering the headset comfortably on a wearer's head. The headset comprises one or more compliant arms and a frame to selectively distribute the weight of the headset and secure the headset to the wearer's head without the need for straps or leavers. The compliant arms provide a normalizing force through elastic body deformation to selectively distribute the weight of the headset.

Compliant mounting arm

A method of fabricating a multi-element fiber scanner includes providing a fiber optic cable having a cladding region and a fiber core and focusing a laser beam at a series of predetermined locations inside the cladding region of the fiber optic cable. The method also includes creating a plurality of damage sites at the predetermined locations, exposing the fiber optic cable to an etchant solution, and preferentially etching the plurality of damage sites to form a base having a base plane and a longitudinal axis orthogonal to the base plane, a retention collar disposed a predetermined distance along the longitudinal axis from the base, a first fiber link including the fiber core, passing through the base plane, and joined to the retention collar, and a plurality of additional links joined to the base, extending from the base to the retention collar, and joined to the retention collar.

Methods and systems for multi-element linkage for fiber scanning display having unified construction formed by etching

A method of operating a multi-axis fiber scanner having a base including a base plane includes providing a source of electromagnetic radiation, directing the electromagnetic radiation through a fiber link that passes through the base plane of the base along a longitudinal axis orthogonal to the base plane, and supporting a retention collar positioned a distance from the base plane. The method also includes actuating a first piezoelectric actuator among a plurality of piezoelectric actuators to decrease the distance between a first side of the base and the retention collar, actuating a second piezoelectric actuator among the plurality of piezoelectric actuators to increase the distance between a second side of the base and the retention collar, and scanning the fiber link in a scanning plane.

Methods and systems for multi-element linkage for fiber scanning display

A multi-element fiber scanner for scanning electromagnetic imaging radiation includes a base having a base plane and a longitudinal axis orthogonal to the base plane and a fiber link passing through the base in a direction parallel to the longitudinal axis. The fiber link is operatively coupled to at least one electromagnetic radiation source. The multi-element fiber scanner also includes a retention collar disposed a predetermined distance along the longitudinal axis from the base and a first set and a second set of piezoelectric tubes. First and second piezoelectric tubes of the first set are joined to the base and extends from the base and first and second piezoelectric tubes of the second set are joined to the retention collar and extend from the retention collar.

A multi-element fiber scanner for scanning electromagnetic imaging radiation includes a base having a base plane and a longitudinal axis orthogonal to the base plane and a first fiber link passing through the base in a direction parallel to the longitudinal axis. The first fiber link is operatively coupled to at least one electromagnetic radiation source. The multi-element fiber scanner also includes a plurality of additional links joined to the base and extending from the base and a retention collar disposed a predetermined distance along the longitudinal axis from the base. The first fiber link and the plurality of fiber links are joined to the retention collar.

The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Antiviral phosphonate analogs

A compound of formula 1 and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.

Method and compositions for treating hematological malignancies

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein:

Anti-proliferative compounds, compositions, and methods of use thereof

Specifically substituted pyrido(3,2-d)pyrimidine derivatives having the structural formula (I) are useful for the treatment of hepatitis C.

Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C

A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.

Prodrugs of phosphonate nucoleotide analogues

Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds

The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Therapeutic phosphonate compounds

Growing community of inventors

Los Altos, CA, United States of America

William A Lee