E.i. Dupont De Nemours and Company

William A Frey

Alan Robert Craig

Catharine E Looney

Michael A Luddy

Charles C Leflar

Johanne C Dickinson

Robert A Ballas

Donald M Simons

A method is disclosed for determining enzymatic activity in a liquid sample by particle agglutination or inhibition of particle agglutination.

Method for detecting enzymatic activity using particle agglutination

Particle reagents, having polyether polyamine linking groups, for use in turbidimetric immunoassays are provided. These linking agents permit ready covalent attachment of compounds of biological interest to polymer particles and lead to immunoassays of improved precision.

Polyether polyamines as linking agents for particle reagents useful in

Novel particle reagents for light scattering immunoassays are provided. The particle reagents are high refractive index shell-core polymers covalently bonded to compounds of biological interest or analogs thereof. A method of measuring unknown concentrations of these compounds of biological interest by measuring changes in turbidity caused by particle agglutination or its inhibition is also provided.

Covalently bonded high refractive index particle reagents and their use

An apparatus for the separation of theophylline and caffeine contained in body fluids is provided. A macroreticular styrene-divinylbenzene copolymer resin activated by a protic solvent is utilized. The body fluid is eluted with water in an isocratic manner to afford a theophylline sample uncontaminated with caffeine. Such samples are useful in immunoassay procedures for the measurement of theophylline.

Method for the removal of interfering substances in theophylline assays

A method for the separation of theophylline and caffeine contained in body fluids is provided. A macroreticular styrene-divinylbenzene copolymer resin activated by a protic solvent is utilized. The body fluid is eluted with water in an isocratic manner to afford a theophylline sample uncontaminated with caffeine. Such samples are useful in immunoassay procedures for the measurement of theophylline.

Method for the removal of interfering substances, including caffeine, in

Novel particle reagent for light scattering immunoassays are provided. The particle reagents are high refractive index shell-core polymers covalently bonded to compounds of biological interest. A method of measuring unknown concentrations of these compounds of biological interest by measuring changes in turbidity caused by particle agglutination or its inhibition is also provided.

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Wilmington, DE, United States of America

William A Frey