The Dow Chemical Company

Merrell Pharmaceuticals, Inc.

Merrell Dow Pharmaceuticals

Other

University of Texas System

William A Fordyce

William Jack Kruper, Jr

Michael J Fazio

Michael J Mullins

Alan D Cardin

James C Stevens

Thomas A Chamberlin

David A Wilson

Jaime Simon

Joseph R Garlich

Kenneth McMillan

Roberta C Cheng

Douglas K Pollock

A Dean Sherry

Garry E Kiefer

Muthiah N Inbasekaran

Ramaiah Muthyala

Richard Keith Frank

Norton P Peet

R Keith Frank

William J Kruper

William F Goeckeler

Muthiah N Inbaskaran

William F Goeckleler

Sharon Braughman

Machael J Fazio

Sharon Baughman

William F Goeckler

The oligomers of the present invention are polythioureas having 3 to 50 recurring units derived from aromatic diamines substituted with anionic groups, and having a number average molecular weight of less than 10,000. These oligomers are water-soluble, preferably have a rigid backbone, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of AIDS.

Pharmaceutical formulations comprising polythiourea and methods of use

The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.

Narrow poly-and-mono-dispersed anionic oligomers, and their uses,

Narrow poly- and mono-dispersed anionic oligomers

A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.

Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic

A group of functionalized polyaminocarboxamide modified chelators, such as 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)-7-N-(1-carboxymethyl )bis-4,10-N,N-(carboxamidomethyl)cyclododecane and 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)bis-4,7-N,N-(1-carbox ymethyl)-10-N-(carboxamidomethyl)cyclododecane are disclosed. These modified chelators are capable of forming complexes with rare earth-type metal ions. When the complexes are covalently attached to an antibody or antibody fragment, they can be used in therapeutic and diagnostic applications.

Carboxamide modified polyamine chelators and radioactive complexes

A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.

Macrocyclic ligands and complexes

The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moities which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.

Narrow poly- and mono-dispersed anoinic oligomers, and their uses,

A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

Functionalized polyamine chelants

A group of functionalized macrocyclic polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes for cancer.

Macrocyclic congugates and their use as diagnostic and therapeutic agents

Narrow poly- and mono-dispersed anionic oligomers, and their uses,

A group of functionalized polyaminocarboxamide modified chelators that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.

Functionalized polyamine chelants and rhodium complexes thereof for

Novel di(poly-substituted cyclopentadienyl)-allylic uranium complexes can be employed to catalyze the dimerization of propylene to form 4-methyl-1-pentene selectively. The novel catalyst complexes can be prepared from novel di(poly-substituted cyclopentadienyl)-U(IV) monohalo monoallylic complexes.

Uranium (III) catalyst for the selective dimerization of propylene to

A group of functionalized polyamine chelants that form complexes with radioactive rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

Functionalized polyamine chelants and radioactive rhodium complexes

Novel di(poly-substituted cyclopentadienyl)-allylic uranium complexes can be employed to catalyze the dimerization of propylene to form 4-methyl-1-pentene selectively. The novel catalyst complexes can be prepared from novel di(poly-substituted cyclopentadienyl)-U-(IV) monohalo monoallylic complexes.

Growing community of inventors

Midland, MI, United States of America

William A Fordyce